Patents by Inventor Karen Heichman
Karen Heichman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9546403Abstract: Methods, kits and compositions drawn related to providing controls in diagnostic testing are provided. In one embodiment, a method of verifying proper function of a test for detecting and/or classifying a disease or disorder for which manifestation of a methylated gene is a biomarker is provided. The method includes performing a test for detecting, monitoring, or classifying a disease or disorder, or predisposition thereto, for which manifestation of a methylated gene is a biomarker and verifying proper function of the test by performing (e.g. duplicating or repeating) the test utilizing a control that originates from at least one pregnant female animal. The test includes determining the methylation status of at least one biomarker from a biological sample obtained from an animal subject and verifying proper function of the test by performing the test utilizing a control that originates from at least one pregnant female animal.Type: GrantFiled: December 14, 2012Date of Patent: January 17, 2017Assignee: University of Utah Research FoundationInventors: Jorja DeGrado Warren, Wei Xiong, Karen A. Heichman
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Publication number: 20090087436Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: September 27, 2007Publication date: April 2, 2009Applicant: Myriad Genetics, IncorporatedInventors: Jean-Marc Roch, Karen Heichman
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Publication number: 20090082265Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: October 1, 2007Publication date: March 26, 2009Applicant: Myriad Genetics, IncorporatedInventors: Paul Bartel, Daniel Cimbora, Janice Sugiyama, Daniel A. Wettstein, Karen Heichman
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Publication number: 20070254300Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: April 27, 2007Publication date: November 1, 2007Applicant: Myriad Genetics, IncorporatedInventors: Daniel Cimbora, Karen Heichman, Paul Bartel, Kimberly Mauck, Angie Bush
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Publication number: 20070225209Abstract: The present invention generally relates to methods and compositions for treating neurological disorders and diseases. In addition, methods for selecting therapeutic agents useful for treating neurological disorders and diseases are provided.Type: ApplicationFiled: January 31, 2007Publication date: September 27, 2007Applicant: Myriad Genetics, IncorporatedInventors: Jean-Marc Roch, Paul Bartel, Karen Heichman
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Publication number: 20050222029Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: March 7, 2005Publication date: October 6, 2005Applicant: Myriad Genetics, IncorporatedInventors: Paul Bartel, Daniel Cimbora, Janice Sugiyama, Daniel Wettstein, Karen Heichman
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Publication number: 20050112118Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: October 20, 2003Publication date: May 26, 2005Applicant: Myriad Genetics, IncorporatedInventors: Daniel Cimbora, Karen Heichman, Paul Bartel, Kimberly Mauck, Angie Bush
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Publication number: 20040226056Abstract: The present invention generally relates to methods and compositions for treating neurological disorders and diseases. In addition, methods for selecting therapeutic agents useful for treating neurological disorders and diseases are provided.Type: ApplicationFiled: February 9, 2004Publication date: November 11, 2004Applicant: Myriad Genetics, IncorporatedInventors: Jean-Marc Roch, Paul Bartel, Karen Heichman
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Publication number: 20040214255Abstract: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.Type: ApplicationFiled: August 11, 2003Publication date: October 28, 2004Applicant: Myriad Genetics, IncorporatedInventors: Karen Heichman, Paul Bartel, Janice Sugiyama
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Patent number: 6653102Abstract: The present invention relates to the discovery of protein—protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: GrantFiled: October 11, 2001Date of Patent: November 25, 2003Assignee: Myriad Genetics, Inc.Inventors: Jean-Marc Roch, Paul L. Bartel, Karen Heichman, Kimberly Mauck, Max Dufford
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Publication number: 20030186317Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: October 9, 2001Publication date: October 2, 2003Applicant: Myriad Genetics, Inc.Inventors: Jean-Marc Roch, Paul L. Bartel, Karen Heichman
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Publication number: 20030068630Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: March 21, 2002Publication date: April 10, 2003Applicant: Myriad Genetics, Inc.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20030064408Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: January 4, 2002Publication date: April 3, 2003Applicant: MYRIAD GENETICS, INC.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20030055219Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: December 14, 2001Publication date: March 20, 2003Applicant: MYRIAD GENETICS, INC.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20030054515Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: December 21, 2001Publication date: March 20, 2003Applicant: MYRIAD GENETICS, INC.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20030032592Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: December 20, 2001Publication date: February 13, 2003Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20030032058Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: December 14, 2001Publication date: February 13, 2003Applicant: MYRIAD GENETICS, INC.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20020197626Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: March 15, 2002Publication date: December 26, 2002Applicant: Myriad Genetics, Inc.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20020165352Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitis (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: December 21, 2001Publication date: November 7, 2002Applicant: MYRIAD GENETICS, INC.Inventors: Daniel M. Cimbora, Karen Heichman, Paul L. Bartel
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Publication number: 20020164655Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.Type: ApplicationFiled: October 11, 2001Publication date: November 7, 2002Applicant: Myriad Genetics, Inc.Inventors: Jean-Marc Roch, Paul L. Bartel, Karen Heichman