Patents by Inventor Karen J. Brunke

Karen J. Brunke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABILIZED THERAPEUTIC AND IMAGING AGENTS
    Publication number: 20100111840
    Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.
    Type: Application
    Filed: June 4, 2009
    Publication date: May 6, 2010
    Inventors: Mark David BEDNARSKI, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
  • Stabilized therapeutic and imaging agents
    Publication number: 20040223911
    Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.
    Type: Application
    Filed: June 8, 2004
    Publication date: November 11, 2004
    Inventors: Mark David Bednarski, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
  • Targeted therapeutic lipid constructs
    Publication number: 20040067196
    Abstract: Novel therapeutic lipid constructs comprising a lipid construct, an anti-cell surface targeting agent, and a radiotherapeutic metal ion are disclosed.
    Type: Application
    Filed: March 27, 2003
    Publication date: April 8, 2004
    Inventors: Karen J. Brunke, Charles A. Wartchow, Jeffrey L. Cleland
  • Stabilized therapeutic and imaging agents
    Publication number: 20020197210
    Abstract: Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.
    Type: Application
    Filed: March 8, 2002
    Publication date: December 26, 2002
    Inventors: Mark David Bednarski, Neal Edward DeChene, John S. Pease, Charles Aaron Wartchow, Karen J. Brunke
  • Thiol protease inhibitor
    Patent number: 5629469
    Abstract: A novel thiol protease inhibitor peptide is isolated from Diabrotica virgifera designated virgiferin. The DNA encoding virgiferin and modified virgiferin peptides are claimed. These sequences maybe cloned into vectors and used to transform plants conferring reduced susceptibility to damage by plant pests that have thiol proteases as digestive enzymes including insects and nematodes and particularly Coleopteran insects.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: May 13, 1997
    Assignee: Sandoz Ltd.
    Inventors: Camille Deluca-Flaherty, Victor J. Chan, Liliana E. C. Scarafia, Karen J. Brunke
  • Plant promoter
    Patent number: 5612472
    Abstract: A Brassica promoter (hsp80) has been isolated which can provide for constitutive expression of heterologous genes in a wide range of tissues and organs. Various deletion mutants and hybrid promoters are described which retain activity and/or which show enhanced activity. Upstream activating sequences are described which separately and in combination can provide for constitutive gene expression. These sequences can also confer constitutive expression on heterologous, non-constitutive promoters.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: March 18, 1997
    Assignee: Sandoz Ltd.
    Inventors: Stacy L. Wilson, Karen J. Brunke