Patents by Inventor Karen J. Coffman

Karen J. Coffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[2,3-d]pyrimidine derivatives
    Patent number: 10966980
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: April 6, 2021
    Assignee: Pfizer Inc.
    Inventors: Michael L. Vazquez, Neelu Kaila, Jamison B. Tuttle, Patrick Robert Verhoest, Matthew R. Reese, Karen J. Coffman, Tarek Samad, James M. Duerr, Simone Sciabola, Mihir D. Parikh
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20160045508
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.
    Type: Application
    Filed: August 10, 2015
    Publication date: February 18, 2016
    Applicant: Pfizer Inc.
    Inventors: Michael L. VAZQUEZ, Neelu KAILA, Jamison B. TUTTLE, Patrick Robert VERHOEST, Matthew R. REESE, Karen J. COFFMAN, Tarek SAMAD, James M. DUERR, Simone SCIABOLA, Mihir D. PARIKH
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7951958
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 31, 2011
    Assignee: Pfizer Inc.
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7795447
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: September 14, 2010
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Imidazole compounds for the treatment of neurological disorders
    Patent number: 7781435
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 24, 2010
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20100184737
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 22, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20100168107
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 1, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20080227781
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: January 9, 2008
    Publication date: September 18, 2008
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Sulfonamide compounds for the treatment of neurodegenerative disorders
    Patent number: 7345095
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: March 18, 2008
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7342118
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: March 11, 2008
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Sulfonamide compounds for the treatment of neurodegenerative disorders
    Patent number: 7163942
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 16, 2007
    Assignee: Pfizer Inc.
    Inventors: Michael A. Brodney, Karen J. Coffman
  • 5HT7 Antagonists and inverse agonists
    Publication number: 20040229874
    Abstract: The present invention relates to compounds of formula I, 1
    Type: Application
    Filed: January 27, 2004
    Publication date: November 18, 2004
    Applicant: Pfizer Inc.
    Inventors: Gene Michael Bright, Karen J. Coffman