Patents by Inventor Karen Jean Froning

Karen Jean Froning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IgG bispecific antibodies and processes for preparation
    Patent number: 11976136
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: May 7, 2024
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Hector Aldaz, Shane Krummen Atwell, Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • Methods for Producing Fabs and IgG Bispecific Antibodies
    Publication number: 20240043552
    Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 8, 2024
    Inventors: Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • Methods for producing fabs and IgG bispecific antibodies
    Patent number: 11820828
    Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: November 21, 2023
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • PROTEINS COMPRISING T-CELL RECEPTOR CONSTANT DOMAINS
    Publication number: 20220306720
    Abstract: Provided herein are proteins comprising T-cell receptor (TCR) constant domains with one or more stabilization mutations, nucleic acids encoding such proteins, and methods of making and using such proteins.
    Type: Application
    Filed: September 2, 2020
    Publication date: September 29, 2022
    Inventors: Stephen J. DEMAREST, Karen Jean FRONING, Brian Arthur KUHLMAN, Jack Barton MAGUIRE
  • IgG Bispecific Antibodies and Processes for Preparation
    Publication number: 20210054103
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Application
    Filed: July 17, 2020
    Publication date: February 25, 2021
    Inventors: Hector ALDAZ, Shane Krummen ATWELL, Stephen John DEMAREST, Karen Jean FRONING, Brian Arthur KUHLMAN, Andrew Philip LEAVER-FAY
  • IgG bispecific antibodies and processes for preparation
    Patent number: 10774156
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: September 15, 2020
    Assignees: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Hector Aldaz, Shane Krummen Atwell, Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • Methods for Producing Fabs and IgG Bispecific Antibodies
    Publication number: 20190292268
    Abstract: The present invention provides methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in CH1/CL interface, Fabs and IgG bi-specific antibodies produced according to said processes as well as nucleic acids, vectors and host cells encoding the same.
    Type: Application
    Filed: December 14, 2017
    Publication date: September 26, 2019
    Applicants: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay
  • IgG Bispecific Antibodies and Processes for Preparation
    Publication number: 20180009908
    Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.
    Type: Application
    Filed: January 21, 2016
    Publication date: January 11, 2018
    Applicants: Eli Lilly and Company, The University of North Carolina at Chapel Hill
    Inventors: Hector Aldaz, Shane Krummen Atwell, Stephen John Demarest, Karen Jean Froning, Brian Arthur Kuhlman, Andrew Philip Leaver-Fay