Abstract: The present disclosure provides methods of inhibiting cell proliferation signaling in a cell. The present disclosure further provides compositions for inhibiting cell proliferation signaling in a cell. The methods and compounds have a range of utilities as therapeutics, diagnostics, and research tools.

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are applicable for treating cancer and other diseases.

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are also applicable for treating cancer and other diseases.

Abstract: The present disclosure provides isolated polypeptide comprising an antigen binding unit directed to a cellular targete bound by an exogenous molecule. The polypeptides, cells comprising the same are useful for targeting intracellular targets or intracellular portions of a target. The compositions and methods disclosed herein have a range of utilities as therapeutics, diagnostics, research tools.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: When using graphical diagrams, cutting and pasting operations may take advantage of predefined relationships to intelligently insert and remove items from the diagram. A text data model may be interpreted sequentially or hierarchically to construct various diagrams. Pasting operations will bring new data into the diagram and data model while conforming the new data to the diagram definition. Cutting operations may cause the data model and diagram to be healed to conform to the diagram definition.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: When using graphical diagrams, cutting and pasting operations may take advantage of predefined relationships to intelligently insert and remove items from the diagram. A text data model may be interpreted sequentially or hierarchically to construct various diagrams. Pasting operations will bring new data into the diagram and data model while conforming the new data to the diagram definition. Cutting operations may cause the data model and diagram to be healed to conform to the diagram definition.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: Techniques for filtering and promoting application store applications are described that can be employed to provide filtered application information and/or application promotions to client devices. The filtering and promoting can be based at least in part upon system information that describes configurations and capabilities of the client devices. In one or more embodiments, various system information for a client device is detected. The detected system information for the client device is used to filter application data in an application catalog. Page information to be provided to the client device for interaction with the application catalog is then ascertained using the filtered application data. The page information is sufficient to enable the client device to render targeted application store pages having filtered application information and/or promotions that are selected based on the detected system information.

Abstract: Techniques for filtering and promoting application store applications are described that can be employed to provide filtered application information and/or application promotions to client devices. The filtering and promoting can be based at least in part upon system information that describes configurations and capabilities of the client devices. In one or more embodiments, various system information for a client device is detected. The detected system information for the client device is used to filter application data in an application catalog. Page information to be provided to the client device for interaction with the application catalog is then ascertained using the filtered application data. The page information is sufficient to enable the client device to render targeted application store pages having filtered application information and/or promotions that are selected based on the detected system information.

Abstract: Techniques for filtering and promoting application store applications are described that can be employed to provide filtered application information and/or application promotions to client devices. The filtering and promoting can be based at least in part upon system information that describes configurations and capabilities of the client devices. In one or more embodiments, various system information for a client device is detected. The detected system information for the client device is used to filter application data in an application catalog. Page information to be provided to the client device for interaction with the application catalog is then ascertained using the filtered application data. The page information is sufficient to enable the client device to render targeted application store pages having filtered application information and/or promotions that are selected based on the detected system information.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: Techniques for application store topics are described that enable collaboration on application store content between a service provider and third-party collaborators. A framework of topics can be defined to include a plurality of topics to organize application data within pages for interaction with an application catalog. Collaborators can opt to submit content for one or more of the topics that are defined as customizable. The submitted content from collaborators can be incorporated into the topics and/or can replace default content provided for the topic. Different topics within the application store pages can be configured as separate and independent topic containers that can derive content from different sources. In at least some embodiments, content provided for a particular topic container within a page is selected based upon a particular type of device that navigates to the page and/or various device criteria associated with the device.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: Managing data across a semantic data view and a presentation data view may be provided. A semantic model may be represented in a semantic data view and a presentation model may be represented in a presentation data view. The presentation model may correspond to a graphical representation of the semantic model. In addition, a command may be received directed toward the semantic data view or the presentation data view. The semantic model and the presentation model may be operated upon according to the received command. Furthermore, the semantic model represented in the semantic data view and the presentation model represented in the presentation data view may be updated in response to operating on the semantic model and the presentation model according to the received command. The semantic model and the presentation model may be simultaneously maintained in a volatile memory in a computer.

Abstract: A method and system for rendering graphics based on user customizations in a computer graphics application are disclosed. The customizations relate to various properties of one or more graphical elements in the graphic. Such properties include positioning, size, formatting and other visual attributes associated with the graphical elements. These properties may be defined as either semantic properties or presentation properties. Semantic properties are persistent across all graphic definitions. Presentation properties are specific to the graphic definition to which each particular graphic belongs. Thus, a customization to a semantic property of a displayed graphic is preserved in memory for application not only to the currently displayed graphic, but also to all other graphic definitions that may be displayed in the future. In contrast, a customization to a presentation property is only preserved for the currently displayed graphic, and thus not preserved for all other graphic definitions.

Abstract: When using graphical diagrams, cutting and pasting operations may take advantage of predefined relationships to intelligently insert and remove items from the diagram. A text data model may be interpreted sequentially or hierarchically to construct various diagrams. Pasting operations will bring new data into the diagram and data model while conforming the new data to the diagram definition. Cutting operations may cause the data model and diagram to be healed to conform to the diagram definition.

Abstract: When using graphical diagrams, cutting and pasting operations may take advantage of predefined relationships to intelligently insert and remove items from the diagram. A text data model may be interpreted sequentially or hierarchically to construct various diagrams. Pasting operations will bring new data into the diagram and data model while conforming the new data to the diagram definition. Cutting operations may cause the data model and diagram to be healed to conform to the diagram definition.