Patents by Inventor Karen Kotkow

Karen Kotkow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating pancreatic or liver cancer using hedgehog antagonists
    Patent number: 8357368
    Abstract: The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: January 22, 2013
    Assignee: Curis, Inc.
    Inventors: Henryk Dudek, Irina Karavanov, Carmen Pepicelli, Karen Kotkow, Lee L. Rubin
  • METHODS OF INHIBITING UNWANTED CELL PROLIFERATION USING HEDGEHOG ANTAGONISTS
    Publication number: 20110008333
    Abstract: The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
    Type: Application
    Filed: April 8, 2010
    Publication date: January 13, 2011
    Applicant: CURIS, INC.
    Inventors: HENRYK DUDEK, IRINA KARAVANOV, CARMEN PEPICELLI, KAREN KOTKOW, LEE L. RUBIN
  • Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
    Patent number: 7708998
    Abstract: The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: May 4, 2010
    Assignee: Curis, Inc.
    Inventors: Henryk Dudek, Irina Karavanov, Carmen Pepicelli, Karen Kotkow, Lee L. Rubin
  • Angiogenesis-modulating compositions and uses
    Patent number: 7498304
    Abstract: Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating tissue repair and in the treatment of many forms of cancer.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: March 3, 2009
    Assignee: Curis, Inc.
    Inventors: Karen Kotkow, Lee L. Rubin
  • Angiogenesis-modulating compositions and uses
    Publication number: 20050054568
    Abstract: Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating tissue repair and in the treatment of many forms of cancer.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 10, 2005
    Inventors: Leona Ling, Michele Sanicola-Nadel, Karen Kotkow, Lee Rubin
  • Stem cell-based methods for identifying and characterizing agents
    Publication number: 20050019801
    Abstract: The present invention provides methods of identifying and/or characterizing agents that promote differentiation of stem cells to a particular differentiated cell type. The invention further provides methods of treating injuries and degenerative diseases by administering agents that promote the differentiation of stem cells to particular differentiated cell types.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 27, 2005
    Applicant: Curis, Inc.
    Inventors: Lee Rubin, Karen Kotkow, Cheng-Jung Lai
  • Hedgehog antagonists, methods and uses related thereto
    Publication number: 20040110663
    Abstract: The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
    Type: Application
    Filed: August 29, 2003
    Publication date: June 10, 2004
    Inventors: Henryk Dudek, Irina Karavanov, Carmen Pepicelli, Karen Kotkow, Lee L. Rubin