Patents by Inventor Karen Krapcho

Karen Krapcho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric metabotropic glutamate receptors and uses thereof
    Publication number: 20050186658
    Abstract: The present invention provides chimeric receptors that include an extracellular domain from a metabotropic glutamate receptor and a non-native signal peptide, e.g., a calcium receptor signal peptide. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.
    Type: Application
    Filed: October 15, 2004
    Publication date: August 25, 2005
    Inventors: Ashwani Gupta, Pamela Jacobson, Keith Jarvie, Karen Krapcho, Laura Storjohann, Thomas Stormann
  • 16 KDA insecticidal toxin from bracons hebetor, nucleic acids encoding said toxin, and methods of use
    Patent number: 6156539
    Abstract: This invention relates to the purification of a group of insecticidally effective toxins isolated from the wasp, Bracon hebetor, characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for two of these toxins have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant toxins, as well as methods of utilizing these toxins as insecticidal agents.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: December 5, 2000
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Janice H. Johnson, Robert M. Kral, Jr., Karen Krapcho
  • Insecticidal toxins from Bracon hebetor nucleic acid encoding said toxin and methods of use
    Patent number: 5874298
    Abstract: This invention relates to the purification of a group of insecticidally effective toxins isolated from the wasp, Bracon hebetor, characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for two of these toxins have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant toxins, as well as methods of utilizing these toxins as insecticidal agents.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: February 23, 1999
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Janice H. Johnson, Robert M. Kral, Jr., Karen Krapcho
  • Insecticidal peptides from spider venom
    Patent number: 5688764
    Abstract: This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for three of these peptides have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: November 18, 1997
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Janice H. Johnson, Robert M. Kral, Jr., Karen Krapcho