Patents by Inventor Karen L. Valentino
Karen L. Valentino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6136786Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: September 9, 1999Date of Patent: October 24, 2000Assignee: Elan Pharmaceuticals, Inc.Inventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 6087091Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: April 23, 1999Date of Patent: July 11, 2000Assignee: Elan Pharmaceuticals, Inc.Inventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 5994305Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: August 21, 1998Date of Patent: November 30, 1999Assignee: Elan Pharmaceuticals, Inc.Inventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 5990137Abstract: The instant methods employs pharmaceutical compositions comprising aromatic azines; and imines, of the Formula 1 to selectively inhibit inflammation by preventing the oxidating burst from phagocytic leukocytes caused by NADPH Oxidase.Type: GrantFiled: June 5, 1998Date of Patent: November 23, 1999Assignee: Idun Pharmaceuticals, Inc.Inventors: Robert J. Ternansky, Karen L. Valentino, Donald S. Karanewsky
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Patent number: 5939460Abstract: The instant methods employs pharmaceutical compositions comprising aromatic azines; and imines, of the Formula 1 to selectively inhibit inflammation by preventing the oxidating burst from phagocytic leukocytes caused by NADPH Oxidase.Type: GrantFiled: July 8, 1996Date of Patent: August 17, 1999Assignee: Idun Pharmaceuticals, Inc.Inventors: Robert J. Ternansky, Karen L. Valentino, Donald S. Karanewsky
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Patent number: 5859186Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: July 3, 1996Date of Patent: January 12, 1999Assignee: Neurex CorporationInventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 5824645Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: November 1, 1996Date of Patent: October 20, 1998Assignee: Neurex CorporationInventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 5587454Abstract: Disclosed are novel omega conotoxin peptides effective in producing analgesia.Type: GrantFiled: April 15, 1993Date of Patent: December 24, 1996Assignee: Neurex CorporationInventors: Alan Justice, Tejinder Singh, Kishor C. Gohil, Karen L. Valentino, George P. Miljanich
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Patent number: 5559095Abstract: A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.Type: GrantFiled: November 12, 1991Date of Patent: September 24, 1996Assignee: Neurex CorporationInventors: George P. Miljanich, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Robert S. Bitner, Donald H. Yamashiro
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Patent number: 5424218Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.Type: GrantFiled: November 4, 1993Date of Patent: June 13, 1995Assignee: Neurex CorporationInventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro
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Patent number: 5364842Abstract: A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit voltage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega-conopeptide MVIIA binding sites present in neuronal tissue.Type: GrantFiled: June 23, 1993Date of Patent: November 15, 1994Assignee: Neurex CorporationInventors: Alan Justice, Tejinder Singh, Kishor C. Gohil, Karen L. Valentino
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Patent number: 5264371Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.Type: GrantFiled: March 23, 1992Date of Patent: November 23, 1993Assignee: Neurex CorporationInventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
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Patent number: 5189020Abstract: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.Type: GrantFiled: August 2, 1990Date of Patent: February 23, 1993Assignee: Neurex CorporationInventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro, Makoto Tsubokawa
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Patent number: 5051403Abstract: A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.Type: GrantFiled: November 22, 1989Date of Patent: September 24, 1991Assignee: Neurex CorporationInventors: George P. Miljanich, Robert S. Bitner, Stephen S. Bowersox, James A. Fox, Karen L. Valentino, Donald H. Yamashiro