Abstract: The present disclosure provides methods of inhibiting cell proliferation signaling in a cell. The present disclosure further provides compositions for inhibiting cell proliferation signaling in a cell. The methods and compounds have a range of utilities as therapeutics, diagnostics, and research tools.

Abstract: A database system receives a database language query specifying a grouping clause and one or more aggregate result values. The database system generates a pre-aggregation table based on the query. The database system generates an ingest query configured to generate data for populating the pre-aggregation table and a completion query configured to processes data stored in the pre-aggregation table. The database system periodically receives a set of input records and executes the ingest query to generate a set of pre-aggregation records. The set of pre-aggregation records are combined with the pre-aggregation table. The database system executes the completion query on the data stored in the pre-aggregation table to generate a result set and sends the generated result set to the requestor of the results.

Abstract: The present invention provides a method for detecting and treating hematologic malignancies including leukemia such as acute lymphoblastic leukemia (ALL) in a subject and a method for determining disease prognosis among leukemia patients by detecting CD9 expression. A kit and device useful for such methods are also provided. In addition, the present invention provides a composition for treating hematologic malignancies such as leukemia by suppressing CD9 expression or activity.

Abstract: Species are supplied to a flowable layer over a substrate. A property of the flowable layer is modified by implanting the species to the flowable layer. The property comprises a density, a stress, a film shrinkage, an etch selectivity, or any combination thereof.