Patents by Inventor Karen M. Downs

Karen M. Downs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of observing vasculogenesis in vitro using cultured allantois
    Patent number: 6828144
    Abstract: A method of fetal gene therapy is disclosed. In general, the method comprises the steps of identifying a fetus with a genetic defect, obtaining allantois/umbilical cord cells expressing a gene product that ameliorates the genetic defect, and exposing the fetus to the allantois/umbilical cord cells wherein a chimeric allantois is capable of supplying the gene product to the fetus is created. The present invention is also a method of examining the effect of test compounds on vasculogenesis and angiogenesis by observing the effect of the test compound on cultured allantoic explants.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: December 7, 2004
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Karen M. Downs
  • CHIMERIC MAMMALIAN ALLANTOIS
    Publication number: 20020039572
    Abstract: A method of fetal gene therapy is disclosed. In general, the method comprises the steps of identifying a fetus with a genetic defect, obtaining allantois/umbilical cord cells expressing a gene product that ameliorates the genetic defect, and exposing the fetus to the allantois/umbilical cord cells wherein a chimeric allantois is capable of supplying the gene product to the fetus is created. The present invention is also a method of examining the effect of test compounds on vasculogenesis and angiogenesis by observing the effect of the test compound on cultured allantoic explants.
    Type: Application
    Filed: June 18, 1999
    Publication date: April 4, 2002
    Inventor: KAREN M. DOWNS