Patents by Inventor Karen M. Frost

Karen M. Frost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160176799
    Abstract: A method for isolating and purifying shikimic acid from a fermentation broth is provided. The method includes performing a liquid-liquid extraction on the fermentation broth with an alcohol solution to generate an extract, crystallizing solids from the extract, dissolving the solids in a second alcohol solution to generate a solution having shikimic acid, and filtering the solution having shikimic acid through a filter that does not contain ion exchange resins. Methods for dehydrating the shikimic acid to yield p-hydroxybenzoic acid are also provided.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Inventors: Karen M. FROST, John W. FROST
  • Patent number: 8080397
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: December 20, 2011
    Assignee: Board of Trustees Operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost
  • Publication number: 20100279368
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Application
    Filed: November 20, 2009
    Publication date: November 4, 2010
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 7642083
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: January 5, 2010
    Assignee: Board of Trustees Operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 7002047
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: February 21, 2006
    Assignee: Board of Trustees Operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost
  • Publication number: 20030203460
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Application
    Filed: May 9, 2003
    Publication date: October 30, 2003
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 6620602
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: September 16, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 6613552
    Abstract: A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 2, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost, David R. Knop
  • Patent number: 6600077
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: July 29, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 6472169
    Abstract: A bioengineered synthesis scheme for the production of shikimic acid from a carbon source is provided. Methods of producing shikimic acid from a carbon source based on the synthesis scheme are also provided.
    Type: Grant
    Filed: September 30, 2000
    Date of Patent: October 29, 2002
    Assignee: Board of Trustees operating Michigan State University
    Inventors: John W. Frost, Karen M. Frost, David R. Knop
  • Publication number: 20020142409
    Abstract: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a earbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.
    Type: Application
    Filed: March 15, 2002
    Publication date: October 3, 2002
    Inventors: John W. Frost, Karen M. Frost
  • Patent number: 5776736
    Abstract: Enhanced efficiency of production of aromatic compounds via the common pathway, as shown in FIG. 1, of a host cell is realized by increasing the expression of enzyme species acting on substrate intermediates in identified rate-limiting reaction steps in the pathway. Prokaryotic cell transformants are described comprising exogenous DNA sequences encoding for the enzymes species, 3-dehydroquinate synthase, shikimate kinase, 5-enolpyruvoyl-shikimate-3-phosphate synthase and chorismate synthase. These transformants can be further transformed with exogenous DNA sequences encoding the enzyme species transketolase and DAHP synthase. In one embodiment of the present invention, one or more of the DNA sequences encoding the enzyme species are incorporated into the genome of the transformant.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: July 7, 1998
    Assignee: Purdue Research Foundation
    Inventors: John W. Frost, Kristi D. Snell, Karen M. Frost