Patents by Inventor Karen M. Grimm

Karen M. Grimm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Preparing a Covalently Cross Linked Oligomer of Amyloid Beta Peptides
    Publication number: 20100143396
    Abstract: The invention relates to a method for the preparation of a stabilized cross-linked oligomer of amyloid beta using a near-zero length bifunctional cross-linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer's Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5-difluoro-2,4-dinitrobenzene (DFDNB).
    Type: Application
    Filed: June 26, 2006
    Publication date: June 10, 2010
    Inventors: Karen M. Grimm, Joseph G. Joyce, Xiaoping Liang, Denise Nawrocki
  • exopolysaccharide and process
    Patent number: 7157443
    Abstract: A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,?-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: January 2, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Joyce, James C. Cook, III, Chitrananda Abeygunawardana, Karen M. Grimm, Craig T. Przysiecki, Robert W. Hepler, Charlotte C. Ip, Keith Roper, Qiuwei Xu, Kathrin U. Jansen, Paul M. Keller, Leslie D. Cope
  • Staphylococcus aureus exopolysaccharide and process
    Publication number: 20040259838
    Abstract: A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,&bgr;-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
    Type: Application
    Filed: June 9, 2004
    Publication date: December 23, 2004
    Inventors: Joseph G. Joyce, James C. Cook III, Chitrananda Abeygunawardana, Karen M. Grimm, Craig T. Przysiecki, Robert W. Hepler, Charlotte C. Ip, Donald Keith Roper, Qi Wei Xu, Kathrin U. Jansen, Paul M. Keller, Leslie D. Cope