Abstract: The present disclosure provides compounds for the inhibition of soluble epoxide hydrolase and associate disease conditions, as well as a method of treating or preventing disorders in a subject by inhibition of soluble epoxide hydrolase.

Abstract: The present disclosure provides compounds for the inhibition of soluble epoxide hydrolase and associate disease conditions, as well as a method of treating or preventing disorders in a subject by inhibition of soluble epoxide hydrolase.

Abstract: A system for supplying melted thermoplastic material to a dispenser comprises a hopper for storing the thermoplastic material, the hopper having an outlet. A heating grid is at the outlet of the hopper for heating and melting the thermoplastic material. A reservoir is provided into which the melted material flows from the grid. A manifold assembly is connected to the reservoir. The melted material flows into the manifold assembly from the reservoir. The manifold assembly includes connections for supplying the material to a dispenser. The manifold assembly also includes a pump cavity. A pump is mounted in the pump cavity and is capable of being removed from the pump cavity. A drive assembly is connected to drive the pump. A movable carriage supports the drive assembly. The carriage is capable of movement toward and away from the manifold assembly to remove the pump from the cavity and to replace the pump into the cavity.