Abstract: Provided herein is a prosthetic device in patients with ventricular assist device (VAD) support and a closed off aortic valve orifice, which reestablishes the formation of normal fluid flow patterns in the aortic root. The prosthesis includes a circular body having a first surface and a second surface and a projection disposed on the first surface of the body, wherein the projection includes a plurality of walls extending away from the first surface of the body, each wall being positioned such that a first side edge contacts a center of the body, thereby forming a plurality of intercepted arcs, each located between adjacent walls; and a plurality of concave parabolic surfaces, each disposed within an intercepted arc. Also provided are methods of using the prosthetic device to reduce thrombosis formation in patients with VAD support.

Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract: A holder for use with a nipple-topped nursing bottle includes a sleeve portion for covering the nursing bottle. Surrounding the sleeve portion is a ring portion. The ring portion may be grabbed and squeezed by the animal being nursed during the nursing process. Such grabbing and squeezing during the nursing process overcomes the reluctance of the animal to take nourishment through the nipple of nipple-tipped nursing bottle and shortens the time during which an animal may be weaned to a nipple-tipped nursing bottle.

Abstract: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract: This invention provides a device, or product of manufacture, for use as a teaching device for tying knots, or as an aid in tying knots, e.g., as for use by handicapped or disabled individuals. The invention provides device, or product of manufacture, completely automated for tying knots using the device and/or methods of the invention. The invention also provides methods for making and using these devices of the invention.

Abstract: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.

Abstract: An artificial nursing system for use by an infant animal is disclosed. The nursing system comprises a feeding bottle, a nipple and a sleeve. The feeding bottle has a top end and a bottom end, the top end of the feeding bottle is attached to the nipple. A sleeve envelopes the feeding bottle, the sleeve comprises a first section made from an elastic material, wherein the elastic material constricts around the feeding bottle and a second section fixedly attached to the first section, the second section is made from a scent accepting fabric and surrounds the nipple. The first and second sections allow the infant animal to grip the feeding bottle and nipple and the constriction of the first section of the sleeve attaches the sleeve to the feeding bottle.