Abstract: Provided herein is a prosthetic device in patients with ventricular assist device (VAD) support and a closed off aortic valve orifice, which reestablishes the formation of normal fluid flow patterns in the aortic root. The prosthesis includes a circular body having a first surface and a second surface and a projection disposed on the first surface of the body, wherein the projection includes a plurality of walls extending away from the first surface of the body, each wall being positioned such that a first side edge contacts a center of the body, thereby forming a plurality of intercepted arcs, each located between adjacent walls; and a plurality of concave parabolic surfaces, each disposed within an intercepted arc. Also provided are methods of using the prosthetic device to reduce thrombosis formation in patients with VAD support.

Abstract: This invention provides a device, or product of manufacture, for use as a teaching device for tying knots, or as an aid in tying knots, e.g., as for use by handicapped or disabled individuals. The invention provides device, or product of manufacture, completely automated for tying knots using the device and/or methods of the invention. The invention also provides methods for making and using these devices of the invention.