Patents by Inventor Karen McDonald
Karen McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10918703Abstract: The present invention provides plant-made elafin-Fc fusion proteins for treating inflammatory diseases, e.g., inflammatory lung diseases. In certain embodiments, the fusion proteins comprise one or more point mutations, which confer improved properties, such as increased resistance to oxidation, cleavage, and increased half-life. The present invention additionally provides polynucleotides encoding the fusion proteins, recombinant cells and expression vectors, and transgenic plants comprising the fusion protein coding sequences. The present invention further provides methods for the production of the fusion proteins.Type: GrantFiled: October 31, 2018Date of Patent: February 16, 2021Assignee: The Regents of the University of CaliforniaInventors: Karen A. McDonald, Kalimuthu Karuppanan, Carroll E. Cross, Jason P. Eiserich
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Patent number: 10421973Abstract: The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts.Type: GrantFiled: February 13, 2017Date of Patent: September 24, 2019Assignee: The Regents Of The University Of CaliforniaInventors: Karen A. McDonald, Abhaya Dandekar, Bryce W. Falk, Mysore R. Sudarshana, Sandra L. Uratsu, Michael A. Plesha, Ting-Kuo Huang
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Publication number: 20190142914Abstract: The present invention provides plant-made elafin-Fc fusion proteins for treating inflammatory diseases, e.g., inflammatory lung diseases. In certain embodiments, the fusion proteins comprise one or more point mutations, which confer improved properties, such as increased resistance to oxidation, cleavage, and increased half-life. The present invention additionally provides polynucleotides encoding the fusion proteins, recombinant cells and expression vectors, and transgenic plants comprising the fusion protein coding sequences. The present invention further provides methods for the production of the fusion proteins.Type: ApplicationFiled: October 31, 2018Publication date: May 16, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Karen A. McDonald, Kalimuthu Karuppanan, Carroll E. Cross, Jason P. Eiserich
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Publication number: 20170159063Abstract: The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts.Type: ApplicationFiled: February 13, 2017Publication date: June 8, 2017Inventors: Karen A. MCDONALD, Abhaya DANDEKAR, Bryce W. FALK, Mysore R. SUDARSHANA, Sandra L. URATSU, Michael A. PLESHA, Ting-Kuo HUANG
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Patent number: 9617297Abstract: The present disclosure relates to methods of increasing the extraction of an apoplast-targeted recombinant protein in a plant tissue and to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue. The methods involve contacting plant tissue with a rinse fluid on a plurality of occasions to release recombinant protein from the apoplast into the rinse fluid to create an apoplast wash fluid. The resulting content of the recombinant protein in the apoplast wash fluid is higher than the content of the recombinant protein in the apoplast wash fluid from comparable plant tissue contacted with rinse fluid on a single occasion.Type: GrantFiled: October 11, 2013Date of Patent: April 11, 2017Assignee: The Regents of the University of CaliforniaInventors: Karen A. McDonald, Nathaniel J. Kingsbury
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Patent number: 9605270Abstract: The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts.Type: GrantFiled: September 24, 2007Date of Patent: March 28, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Karen A. McDonald, Abhaya Dandekar, Bryce W. Falk, Mysore R. Sudarshana, Sandra L. Uratsu, Michael A. Plesha, Ting-Kuo Huang
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Publication number: 20150140644Abstract: The present disclosure relates to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue, and increasing the yield of recovery of an apoplast-targeted recombinant protein from a plant tissue.Type: ApplicationFiled: November 18, 2014Publication date: May 21, 2015Inventors: Karen A. MCDONALD, Nathaniel J. KINGSBURY
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Patent number: 8993839Abstract: Described herein are viral amplicon-based protein expression systems and methods useful for producing heterologous proteins, such as enzymes, by agroinfiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a heterologous protein, infecting plant cells with the Agrobacterium, allowing expression of the heterologous protein, and recovering the heterologous protein from the plant cells. In one embodiment, the protein produced is an endoglucanase.Type: GrantFiled: July 19, 2011Date of Patent: March 31, 2015Assignee: The Regents of the University of CaliforniaInventors: Minsook Hwang, Benjamin E. Lindenmuth, Karen A. McDonald, Abhaya M. Dandekar, Bryce W. Falk, Sang-Kyu Jung, Nathaniel J. Kingsbury
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Publication number: 20140106434Abstract: The present disclosure relates to methods of increasing the production of an apoplast-targeted recombinant protein in a plant tissue and to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue.Type: ApplicationFiled: October 11, 2013Publication date: April 17, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Karen A. MCDONALD, Nathaniel J. KINGSBURY
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Patent number: 8674178Abstract: Described herein are methods useful for producing proteins, such as enzymes, by agrofiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a cellulase, infecting plant cells with the Agrobacterium, allowing expression of the cellulase, and recovering the cellulase from the plant cells. In one embodiment, the protein produced is an endoglucanase.Type: GrantFiled: August 19, 2009Date of Patent: March 18, 2014Assignee: The Regents of the University of CaliforniaInventors: Karen A. McDonald, Benjamin E. Lindenmuth, Abhaya M. Dandekar, Bryce W. Falk
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Publication number: 20120045818Abstract: Described herein are viral amplicon-based protein expression systems and methods useful for producing heterologous proteins, such as enzymes, by agroinfiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a heterologous protein, infecting plant cells with the Agrobacterium, allowing expression of the heterologous protein, and recovering the heterologous protein from the plant cells. In one embodiment, the protein produced is an endoglucanase.Type: ApplicationFiled: July 19, 2011Publication date: February 23, 2012Applicant: The Regents of the University of CaliforniaInventors: Minsook HWANG, Benjamin E. Lindenmuth, Karen A. McDonald, Abhaya M. Dandekar, Bryce W. Falk, Sang-Kyu Jung, Nathaniel J. Kingsbury
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Publication number: 20120005782Abstract: The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts.Type: ApplicationFiled: September 24, 2007Publication date: January 5, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Karen A. McDonald, Abhaya Dandekar, Bryce W. Falk, Mysore R. Sudarshana, Sandra L. Uratsu, Michael A. Plesha, Ting-kuo Huang
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Publication number: 20110106235Abstract: An introducer deploys an endoluminal device in a distal location from a proximal location. The introducer comprises a retrograde portion, an anterograde portion axially moveable relative to the retrograde portion, a shaft having a distal tip and an anterograde sheath attached to the distal tip, and anchoring means in at least one of the retrograde portion or the anterograde portion for anchoring the device during deployment from its proximal end to its distal end. An inner sheath may be mounted concentrically over the shaft with the endoluminal device mounted concentrically over the inner sheath. The anchoring device may comprise an inflatable balloon mounted radially inside the retrograde portion, a tether, or an extended portion of the endoluminal device confined by a notch in the interface of two sheaths in the retrograde portion of the introducer, or may comprise a holder in the anterograde portion.Type: ApplicationFiled: January 8, 2011Publication date: May 5, 2011Applicant: Boston Scientific Scimed, Inc.Inventors: Patrick A. Haverkost, Paul F. Choulnard, James Weldon, Karen McDonald, Wade M. Johnson
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Patent number: 7892272Abstract: An introducer deploys an endoluminal device in a distal location from a proximal location. The introducer comprises a retrograde portion, an anterograde portion axially moveable relative to the retrograde portion, a shaft having a distal tip and an anterograde sheath attached to the distal tip, and anchoring means in at least one of the retrograde portion or the anterograde portion for anchoring the device during deployment from its proximal end to its distal end. An inner sheath may be mounted concentrically over the shaft with the endoluminal device mounted concentrically over the inner sheath. The anchoring device may comprise an inflatable balloon mounted radially inside the retrograde portion, a tether, or an extended portion of the endoluminal device confined by a notch in the interface of two sheaths in the retrograde portion of the introducer, or may comprise a holder in the anterograde portion.Type: GrantFiled: February 27, 2006Date of Patent: February 22, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Patrick A. Haverkost, Paul F. Chouinard, James Weldon, Karen McDonald, Wade M. Johnson
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Patent number: 7887573Abstract: An introducer deploys an endoluminal device in a distal location from a proximal location. The introducer comprises a retrograde portion, an anterograde portion axially moveable relative to the retrograde portion, a shaft having a distal tip and an anterograde sheath attached to the distal tip, and anchoring means in at least one of the retrograde portion or the anterograde portion for anchoring the device during deployment from its proximal end to its distal end. An inner sheath may be mounted concentrically over the shaft with the endoluminal device mounted concentrically over the inner sheath. The anchoring device may comprise an inflatable balloon mounted radially inside the retrograde portion, a tether, or an extended portion of the endoluminal device confined by a notch in the interface of two sheaths in the retrograde portion of the introducer, or may comprise a holder in the anterograde portion.Type: GrantFiled: February 22, 2002Date of Patent: February 15, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Patrick A. Haverkost, Paul F. Chouinard, James Weldon, Karen McDonald, Wade M. Johnson
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Publication number: 20100055740Abstract: Described herein are methods useful for producing proteins, such as enzymes, by agrofiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a cellulase, infecting plant cells with the Agrobacterium, allowing expression of the cellulase, and recovering the cellulase from the plant cells. In one embodiment, the protein produced is an endoglucanase.Type: ApplicationFiled: August 19, 2009Publication date: March 4, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Karen A. MCDONALD, Benjamin E. Lindenmuth, Abhaya M. Dandekar, Bryce W. Falk
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Patent number: 7235095Abstract: A method for deployment of a multi-part endoluminal device includes deploying a first portion of the device sequentially from its distal end to its proximal end, then deploying a second portion of the device sequentially from its proximal end to its distal end so that its distal end overlaps the first portion proximal end. The system for deploying the endoluminal device includes a first introducer loaded with a first endoluminal device and adapted to deploy the first device sequentially from the distal end to the proximal end, and a second introducer loaded with a second endoluminal device and adapted to anchor the second endoluminal device proximal end while deploying the second endoluminal device sequentially from the proximal end to the distal end.Type: GrantFiled: February 22, 2002Date of Patent: June 26, 2007Assignee: Scimed Life Systems, Inc.Inventors: Patrick A. Haverkost, Paul F. Chouinard, James Weldon, Karen McDonald, Wade M. Johnson, Juan Carlos Parodi
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Publication number: 20060142837Abstract: An introducer deploys an endoluminal device in a distal location from a proximal location. The introducer comprises a retrograde portion, an anterograde portion axially moveable relative to the retrograde portion, a shaft having a distal tip and an anterograde sheath attached to the distal tip, and anchoring means in at least one of the retrograde portion or the anterograde portion for anchoring the device during deployment from its proximal end to its distal end. An inner sheath may be mounted concentrically over the shaft with the endoluminal device mounted concentrically over the inner sheath. The anchoring device may comprise an inflatable balloon mounted radially inside the retrograde portion, a tether, or an extended portion of the endoluminal device confined by a notch in the interface of two sheaths in the retrograde portion of the introducer, or may comprise a holder in the anterograde portion.Type: ApplicationFiled: February 27, 2006Publication date: June 29, 2006Inventors: Patrick Haverkost, Paul Chouinard, James Weldon, Karen McDonald, Waden Johnson
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Patent number: 7045354Abstract: The present invention relates to methods for semi-continuous culture of plant cells in a nutrient medium. The pH of the medium is monitored during the cell culture as a way of monitoring the expression of a product of interest by the cells.Type: GrantFiled: November 14, 2001Date of Patent: May 16, 2006Assignee: The Regents of the University of CaliforniaInventors: Karen A. McDonald, Alan P. Jackman, Melody M. Trexler
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Publication number: 20030163188Abstract: A method for deployment of a multi-part endoluminal device comprises deploying a first portion of the device sequentially from its distal end to its proximal end, then deploying a second portion of the device sequentially from its proximal end to its distal end so that its distal end overlaps the first portion proximal end. The system for deploying the endoluminal device comprises a first introducer loaded with a first endoluminal device and adapted to deploy the first device sequentially from the distal end to the proximal end, and a second introducer loaded with a second endoluminal device and adapted to anchor the second endoluminal device proximal end while deploying the second endoluminal device sequentially from the proximal end to the distal end.Type: ApplicationFiled: February 22, 2002Publication date: August 28, 2003Inventors: Patrick A. Haverkost, Paul F. Chouinard, James Weldon, Karen McDonald, Wade M. Johnson, Juan Carlos Parodi