Patents by Inventor Karen Midthun

Karen Midthun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine against rotavirus diseases and method of preparing same
    Patent number: 4927628
    Abstract: A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: May 22, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Chanock, Albert Kapikian, Karen Midthun, Jorge Flores, Mario Gorziglia, Yasutaka Hoshino, Irene Peres-Schael
  • Vaccine against rotavirus diseases
    Patent number: 4751080
    Abstract: The present invention discloses a vaccine for the prevention of rotavirus caused diseases in humans. The vaccine is prepared from attenuated, immunogenic rhesus rotavirus which has been characterized to be antigenically similar, if not identical, to human rotavirus serotype 3.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: June 14, 1988
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard G. Wyatt, Albert Z. Kapikian, Robert M. Chanock, Karen Midthun, Jorge Flores, Yasutaka Hoshino
  • Vaccine against rotavirus diseases
    Patent number: 4704275
    Abstract: The present invention discloses a vaccine for the prevention of rotavirus caused diseases in humans. The vaccine is prepared from attenuated, immunogenic rhesus rotavirus which has been characterized to be antigenically similar, if not identical, to human rotavirus serotype 3.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: November 3, 1987
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard G. Wyatt, Albert Z. Kapikian, Robert M. Chanock, Karen Midthun, Jorge Flores, Yasutaka Hoshino
  • Genetic reassortment of rotaviruses for production of vaccines and vaccine precursors
    Patent number: 4571385
    Abstract: This invention relates to processes which are used to produce, isolate, and characterize human rotavirus/animal rotavirus reassortants and to produce live attenuated vaccines and vaccine precursors. In the present strategy there is involved the new use of either (1) high titer hyperimmune antisera or (2) monoclonal antisera to select reassortants with the desired human phenotype. A point of novelty is the finding that antiserum or monoclonal antisera alone, so long as it possesses high titer neutralizing activity against only the 34-38Kd glycoprotein or of the animal parent, is sufficient to use for selection of reassortant rotaviruses with human phenotype. Also, the novel products are live attenuated vaccine precursors and vaccines.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: February 18, 1986
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Harry B. Greenberg, Richard G. Wyatt, Albert Z. Kapikian, Anthony R. Kalica, Karen Midthun, Robert M. Chanock