Patents by Inventor Karen Pauwelyn

Karen Pauwelyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
    Patent number: 10457914
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: October 29, 2019
    Assignee: Katholieke Universiteit Leuven
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie
  • Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells
    Patent number: 9057051
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: June 16, 2015
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie
  • Optimized Methods for Differentiation of Cells Into Cells with Hepatocyte and Hepatocyte Progenitor Phenotypes, Cells Produced by the Methods, and Methods for Using the Cells
    Publication number: 20140186954
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Application
    Filed: September 19, 2013
    Publication date: July 3, 2014
    Applicant: Katholieke Universiteit Leuven
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie
  • Optimized Methods for Differentiation of Cells into Cells With Hepatocyte and Hepatocyte Progenitor Phenotypes, Cells Produced by the Methods, and Methods of Using the Cells
    Publication number: 20110287539
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
    Type: Application
    Filed: October 31, 2008
    Publication date: November 24, 2011
    Applicant: Kathoiieke Universitiet Leuven
    Inventors: Karen Pauwelyn, Catherine M. Verfaillie