Patents by Inventor Karen R. Drexler
Karen R. Drexler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7347973Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: GrantFiled: April 4, 2003Date of Patent: March 25, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Publication number: 20040234415Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: ApplicationFiled: April 4, 2003Publication date: November 25, 2004Inventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Patent number: 6818180Abstract: Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a membrane or matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix. The devices also provide for microtitration of fluid samples in fixed volumetric openings containing indicator reagent. Another aspect of the device provides a determination of hematocrit level in whole blood in combination with indicator indication of analyte concentration which can be compensated for the hematocrit level. The devices provided are low cost.Type: GrantFiled: June 14, 2001Date of Patent: November 16, 2004Assignee: Roche Diagnostics Operations, Inc.Inventors: Joel S. Douglas, Karen R. Drexler, James N. Wilson
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Publication number: 20030219357Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: ApplicationFiled: April 4, 2003Publication date: November 27, 2003Inventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Patent number: 6544475Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: GrantFiled: April 10, 2000Date of Patent: April 8, 2003Assignee: Amira MedicalInventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Patent number: 6379915Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.Type: GrantFiled: March 20, 2000Date of Patent: April 30, 2002Assignee: Amira MedicalInventors: Joel S. Douglas, Karen R. Drexler
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Publication number: 20010039057Abstract: Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a membrane or matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix . The devices also provide for microtitration of fluid samples in fixed volumetric openings containing indicator reagent. Another aspect of the device provides a determination of hematocrit level in whole blood in combination with indicator indication of analyte concentration which can be compensated for the hematocrit level. The devices provided are low cost due to efficient manufacturing methods provided.Type: ApplicationFiled: June 14, 2001Publication date: November 8, 2001Inventors: Joel S. Douglas, Karen R. Drexler, James N. Wilson
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Patent number: 6242207Abstract: A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.Type: GrantFiled: October 4, 1999Date of Patent: June 5, 2001Assignee: Amira MedicalInventors: Joel S. Douglas, Karen R. Drexler, John M. Gleisner, John H. Priest
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Patent number: 6106780Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: GrantFiled: January 11, 1999Date of Patent: August 22, 2000Assignee: Amira MedicalInventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Patent number: 6040151Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.Type: GrantFiled: March 22, 1999Date of Patent: March 21, 2000Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler
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Patent number: 5989845Abstract: A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6-(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.Type: GrantFiled: September 10, 1998Date of Patent: November 23, 1999Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler
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Patent number: 5962215Abstract: Devices and methods for utilizing dry chemistry dye indicator systems for body fluid analysis such as glucose level in whole blood are provided by incorporating a porous membrane with a skin side which enables separation of whole blood and visually reading the indicator without removing the red blood cell portion of the blood from the membrane. The devices also enable visual reading of the indicator by use of a cellulose fiber glass composite matrix which provides separation of whole blood in a lateral flow of the blood through the matrix from the input area to a test area of the matrix. Another aspect of the device provides a determination of hematocrit level in whole blood by measuring flow rate through a restricted passageway in the device.Type: GrantFiled: April 5, 1996Date of Patent: October 5, 1999Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler, James N. Wilson
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Patent number: 5885790Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.Type: GrantFiled: March 10, 1998Date of Patent: March 23, 1999Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler
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Patent number: 5872713Abstract: An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.Type: GrantFiled: October 30, 1997Date of Patent: February 16, 1999Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler, Jeffrey N. Roe
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Patent number: 5776719Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.Type: GrantFiled: April 5, 1996Date of Patent: July 7, 1998Assignee: Mercury Diagnostics, Inc.Inventors: Joel S. Douglas, Karen R. Drexler
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Patent number: D381591Type: GrantFiled: May 31, 1996Date of Patent: July 29, 1997Assignee: LifeScan, Inc.Inventors: Edward G. Rice, Ernest J. Kiser, Karen R. Drexler, Jennifer Hahamian, Joel S. Douglas, Victoria Page
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Patent number: D392391Type: GrantFiled: February 23, 1996Date of Patent: March 17, 1998Assignee: Mercury Diagnostics Inc.Inventors: Joel S. Douglas, Karen R. Drexler