Patents by Inventor Karen Retta McLachlan

Karen Retta McLachlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-VLA-4 ANTIBODIES
    Publication number: 20140161794
    Abstract: This invention relates to alpha-4 binding antibodies, and fragments thereof.
    Type: Application
    Filed: April 15, 2011
    Publication date: June 12, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Alexey Lugovskoy, Frederick R. Taylor, Karen Retta McLachlan
  • Novel method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Publication number: 20090047668
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Application
    Filed: June 25, 2007
    Publication date: February 19, 2009
    Applicant: Biogen Idec Inc.
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Patent number: 7235360
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: June 26, 2007
    Assignee: Biogen Idec Inc.
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Patent number: 6841383
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: January 11, 2005
    Assignee: Idec Pharmaceuticals Corporation
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Novel method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Publication number: 20040166528
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Application
    Filed: April 6, 2004
    Publication date: August 26, 2004
    Applicant: Biogen Idec Inc.
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Novel method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Publication number: 20020192820
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Application
    Filed: April 1, 2002
    Publication date: December 19, 2002
    Applicant: IDEC PHARMACEUTICALS Corp.
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Patent number: 6413777
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: July 2, 2002
    Assignee: IDEC Pharmaceuticals Corp.
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Patent number: 5998144
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: December 7, 1999
    Assignee: Idec Pharmaceuticals Corporation
    Inventors: Mitchell R. Reff, Richard Spence Barnett, Karen Retta McLachlan
  • Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
    Patent number: 5830698
    Abstract: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: November 3, 1998
    Assignee: IDEC Pharmaceuticals Corporation
    Inventors: Mitchell E. Reff, Richard Spence Barnett, Karen Retta McLachlan