Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract: Methods and systems are provided for attaching a note to an insurance policy or claim. In some embodiments, an icon next to a part of an insurance policy may indicate whether a note has been attached. In some embodiments, a note may be attached, or a note may be read, by clicking on the corresponding icon next to a component of the policy. In some embodiments, the components of the policy may include policy information and vehicle information. In some embodiments, a main browser page may be displayed for a user and may include a listing of recent policy activity, a “to-do” list, daily news, daily checkpoints, and favorites. Other information and lists may also be provided on the main browser page. In some embodiments, the information and lists on the main browser page, along with a user's profile, may be configured by a user.

Abstract: Disclosed is a method of treatment for alleviating pain and other problems associated with digestive disorders in general and Irritable Bowel Syndrome in particular using glycerin fatty acid esters such as medium and long chain glycerides.