Patents by Inventor Karen Stoffan

Karen Stoffan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel tyrosine kinase inhibitors
    Publication number: 20060079518
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 13, 2006
    Inventors: Mark Wittman, Neelakantan Balasubramanian, Upender Velaparthi, Kurt Zimmermann, Mark Saulnier, Peiying Liu, Xiaopeng Sang, David Frennesson, Karen Stoffan, James Tarrant, Anne Marinier, Stephan Roy
  • Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
    Patent number: 6855698
    Abstract: The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: February 15, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Mark G. Saulnier, Francis Beaulieu, Carol Bachand, Neelakantan Balusubramanian, Byron Hepler Long, David B. Frennesson, Kurt Zimmermann, B. Narasimhulu Naidu, Karen Stoffan, Denis Robert St. Laurent
  • Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
    Publication number: 20030083271
    Abstract: The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
    Type: Application
    Filed: March 22, 2002
    Publication date: May 1, 2003
    Inventors: Edward H. Ruediger, Mark G. Saulnier, Francis Beaulieu, Carol Bachand, Neelakantan Balusubramanian, Byron Hepler Long, David B. Frennesson, Kurt Zimmermann, B. Narasimhulu Naidu, Karen Stoffan, Denis Robert St. Laurent