Abstract: A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

Abstract: Methods for preventing a tissue infection associated with the site of a tissue disruption, such as a surgical incision. The methods include contacting tissue at the site with a composition comprising ?-polylysine in a physiologically-acceptable carrier, such as an isotonic solution, powder or hemostatic material containing ?-polylysine. Also provided are kits for preparing antibacterial ?-polylysine compositions.

Abstract: A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

Abstract: The present invention provides a demineralized bone carrier matrix which is tolerant of bending, stretching and compression. The material comprises a carrier base material cross-linked with a multifunctional polymer. Demineralized bone matrix may be dispersed with the carrier matrix. The demineralized bone carrier matrix may be used as a bone graph substitute. Methods for making the carrier matrix are also provided.

Abstract: An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.

Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.

Abstract: The present invention provides a demineralized bone carrier matrix which is tolerant of bending, stretching and compression. The material comprises a carrier base material cross-linked with a multifunctional polymer. Demineralized bone matrix may be dispersed with the carrier matrix. The demineralized bone carrier matrix may be used as a bone graph substitute. Methods for making the carrier matrix are also provided.

Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.

Abstract: A biomaterial comprising a porous biocompatible structure and a demineralized bone extract coated onto into the pores of the biocompatible structure are provided. The biomaterial may also comprise a demineralized bone gelatin where the gelatin may be coated over the extract coating or mixed with the extract coating before being applied to the biocompatible structure. Methods for making the biomaterial are also provided.

Abstract: A felt for repairing soft tissue defects comprising a membranous collagen substrate and a bioresorbable fiber felted onto the collagen substrate. Methods of preparing a felt and methods of repairing soft tissue damage with a felt are also provided.

Abstract: A shelf-stable, demineralized, and freeze-dried osteochondral plug comprising cartilage, subchondral bone, and the underlying cancellous bone is provided. Methods of preparing the demineralized osteochondral plug and methods of repairing a defect site are also provided.

Abstract: Methods for grafting whole superficial articular cartilage are provided. A defect site is prepared to receive the whole superficial cartilage graft by removing a region of tissue. A whole superficial cartilage is obtained from a selected articular cartilage site. The whole superficial cartilage graft is attached to the prepared deficit site to sufficiently reduce movement of the whole superficial cartilage.

Abstract: A felt for repairing soft tissue defects comprising a membranous collagen substrate and a bioresorbable fiber felted onto the collagen substrate. Methods of preparing a felt and methods of repairing soft tissue damage with a felt are also provided.

Abstract: A method for coating a biocompatible substrate with an antibiotic is provided. The method includes dissolving at least one antibiotic in an antibiotic compatible solvent to provide an antibiotic solution. The antibiotic solution is applied to the substrate and the antibiotic compatible solvent is removed from the substrate. Methods of preparing a metallic implant and methods of providing localized antibiotic activity are also provided.

Abstract: Methods for extracting heparin-binding growth factors from whole blood comprising contacting whole blood with a heparin-conjugated system to immobilize a conjugated fraction comprising the heparin-binding growth factors; separating a non-conjugated fraction from the system; and releasing the heparin-binding growth factors are provided. Kits include a heparin-conjugate immobilized to the surface of a substrate; and a device to withdraw whole blood from a human or animal subject. Methods of promoting tissue health with the growth factors are also provided.

Abstract: A multilayer microperforated implant comprising a plurality of microperforated substrate layers is provided. Methods of forming a microperforated implant comprise providing at least one substrate layer; perforating at least a region of the substrate layer; and dehydrating the substrate layer. Methods of augmenting a site in need of repair with the microperforated implant are also provided.

Abstract: A method for forming a patch using a laminated material and a process for forming the laminated material. Also a plurality of patches using the laminated material for various implantation purposes into an anatomy. In addition, an implant method for implanting one or a plurality of the selected patches for various reasons.