Patents by Inventor Karen VANDENBROUCKE

Karen VANDENBROUCKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MCL-1 BINDING ALPHABODIES AND USES THEREOF
    Publication number: 20240317807
    Abstract: Present invention provides polypeptides capable of specifically binding myeloid cell leukemia 1 (MCL-1) comprising at least one Alphabody structure characterized in that HRS2 comprises a MCL-1 binding region; the polypeptide comprises an albumin binding region conjugated to the C-terminus of HRS3; HRS1, HIRS2 and HRS3 form a triple-stranded, anti-parallel, alpha-helical coiled coil; and HRS1, HRS2, HRS3 and the albumin binding region together form a five-stranded alpha-helical bundle. Also provided herein is the use of these polypeptides for use in treating a neoplastic disease.
    Type: Application
    Filed: January 27, 2022
    Publication date: September 26, 2024
    Inventors: Ignace LASTERS, Johan DESMET, Stefan LOVERIX, Karen VANDENBROUCKE, Philippe ALARD, Sabrina DEROO