Abstract: A suspect transaction dataset may be generated from screening a transaction dataset against a master suspect list. Often, this screening process results in a large percentage of false positives hits distributed among the data in the suspect transaction dataset. Among other things, embodiments of the invention provide systems and methods for removing the false positives from a suspect transaction dataset. Some embodiments of the invention use detailed decision matrices to generate, analyze, and cull the dataset. Other embodiments use multi-tiered screening with iterative feedback loops to perform those and other dataset functions.