Abstract: A method, apparatus and computer program product are provided herein for ascertaining a demand of promotions. An example method comprises receiving, from one or more consumers, at least one consumer request for at least one of one or more requested promotions or one or more requested providers, generating an aggregated list of the at least one of the one or more requested promotions or the one or more requested providers, ranking the aggregated list of the at least one consumer request, and causing one or more ranked lists to be distributed to at least one sales resource.

Abstract: A method, apparatus and computer program product are provided herein for ascertaining a demand of promotions. An example method comprises receiving, from one or more consumers, at least one consumer request for at least one of one or more requested promotions or one or more requested providers, generating an aggregated list of the at least one of the one or more requested promotions or the one or more requested providers, ranking the aggregated list of the at least one consumer request, and causing one or more ranked lists to be distributed to at least one sales resource.

Abstract: Calcium channels in a variety of tissues may contain different subunits, including several different ? (gamma) subunits. We report studies regarding structural features of certain gamma subunits, for example the N-terminal first transmembrane domain (TM1) of the subunit ?6. We disclose that certain structural motifs, for example a GxxxG-like structural motif as described herein, can mediate subunit function for calcium channels. A particular peptide motif that has been identified as significant for the ability to mediate a decrease in calcium current is GxxxA. Compositions and methods are disclosed which are useful in modifying calcium regulation in mammalian cells. In various embodiments, calcium current is modified.