Abstract: Disclosed herein ar methods that are useful for treating a subject who has a pathogenic infection, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); reducing the likelihood of the subject from being infected by a pathogen; and for reducing the transmission of a pathogen from a subject to others. The methods utilize a compound disclosed in Table 1 or Table 4 herein, optionally in combination with an additional agent such as an anti-infective agent.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: A platform for connecting to a CCS7 network for supporting concurrently running CCS related applications. Copies of the SUs flowing through the network are sent to the platform where the FISUs, LSSUs and MSUs are filtered to provide the desired SU type for each of the applications. The MSUs are filtered by MSU category and MSU type within category into groups of MSUs of particular interest to the applications, respectively. Linked lists of filter elements associated with the respective linksets of the CCS7 network perform the filtering by comparing category and type fields to the MSU categories and types to form the groups. Filter change data received at a user interface is utilized to modify the filters.

Abstract: A platform for connecting to a CCS7 network for supporting concurrently running CCS related applications. Copies of the SUs flowing through the network are sent to the platform where the FISUs, LSSUs and MSUs are filtered to provide the desired SU type for each of the applications. The MSUs are filtered by MSU category and MSU type within category into groups of MSUs of particular interest to the applications, respectively. Linked lists of filter elements associated with the respective linksets of the CCS7 network perform the filtering by comparing category and type fields to the MSU categories and types to form the groups. Filter change data received at a user interface is utilized to modify the filters.