Patents by Inventor Karena Kosco

Karena Kosco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and enrichment of nucleic acid sequences
    Patent number: 9725755
    Abstract: The present disclosure relates to the enrichment of target nucleic acid sequences present in low-abundance relative to corresponding non-target or reference nucleic acid sequence in a sample. In particular, the methods allow for a substantially greater level of detection sensitivity of target sequence by orders of magnitude enrichment of a low-abundance sequence.
    Type: Grant
    Filed: September 3, 2016
    Date of Patent: August 8, 2017
    Assignee: Trovagene, Inc.
    Inventors: Jason Poole, Saege Handcock, Karena Kosco, Vlada Melnikova, Peter Croucher, Tim Lu, Mark Erlander, Errin Samuelsz
  • CONCENTRATING NUCLEIC ACIDS IN URINE
    Publication number: 20170096661
    Abstract: Provided is a method for concentrating nucleic acids in urine which can be performed without use of toxic reagents and without centrifugation steps. The method allows a 10× or greater concentration of the nucleic acids, removes impurities, and allows processing of volumes greater than 20 ml as a single sample.
    Type: Application
    Filed: October 20, 2016
    Publication date: April 6, 2017
    Applicant: TROVAGENE, INC
    Inventors: Karena Kosco, Jason Poole, Mark G. Erlander
  • SYNTHESIS AND ENRICHMENT OF NUCLEIC ACID SEQUENCES
    Publication number: 20170009276
    Abstract: The present disclosure relates to the enrichment of target nucleic acid sequences present in low-abundance relative to corresponding non-target or reference nucleic acid sequence in a sample. In particular, the methods allow for a substantially greater level of detection sensitivity of target sequence by orders of magnitude enrichment of a low-abundance sequence.
    Type: Application
    Filed: September 3, 2016
    Publication date: January 12, 2017
    Applicant: Trovagene, Inc.
    Inventors: Jason Poole, Saege Handcock, Karena Kosco, Vlada Melnikova, Peter Croucher, Tim Lu, Mark Erlander, Errin Samuelsz
  • SYNTHESIS AND ENRICHMENT OF NUCLEIC ACID SEQUENCES
    Publication number: 20160273022
    Abstract: The present disclosure relates to the enrichment of target nucleic acid sequences present in low-abundance relative to corresponding non-target or reference nucleic acid sequence in a sample. In particular, the methods allow for a substantially greater level of detection sensitivity of target sequence by orders of magnitude enrichment of a low-abundance sequence.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 22, 2016
    Inventors: Jason Poole, Saege Handcock, Karena Kosco, Vlada Melnikova, Peter Croucher, Tim Lu, Mark Erlander, Errin Samuelsz
  • DETECTING MUTATIONS IN DISEASE OVER TIME
    Publication number: 20160115556
    Abstract: Provided is a method determining responsiveness to a treatment in a patient with a cancer.
    Type: Application
    Filed: January 2, 2016
    Publication date: April 28, 2016
    Applicant: Trovagene, Inc.
    Inventors: Mark G. Erlander, Karena Kosco, Cecile Rose Vibat
  • DETECTING MUTATIONS IN DISEASE OVER TIME
    Publication number: 20150139946
    Abstract: Provided is a method for monitoring a gene mutation associated with a cancer in a patient over time. Also provided is a method of selecting and/or applying treatment or therapy for a subject.
    Type: Application
    Filed: October 19, 2014
    Publication date: May 21, 2015
    Inventors: Mark G. Erlander, Karena Kosco, Cecile Rose Vibat
  • DETECTING AND MONITORING MUTATIONS IN HISTIOCYTOSIS
    Publication number: 20150132256
    Abstract: Provided is methods of detecting a mutation in a histiocytosis patient. Also provided is methods of selecting and/or applying treatment or therapy for a histiocytosis patient. Further provided is a method of treating a patient having a histiocytosis.
    Type: Application
    Filed: October 18, 2014
    Publication date: May 14, 2015
    Inventors: Filip Janku, Mark G. Erlander, Cecile Rose Vibat, Karena Kosco, Abdel-Wahab Omar, Eli L. Diamond, David M. Hyman
  • NON-INVASIVE FETAL RHD GENOTYPING FROM MATERNAL WHOLE BLOOD
    Publication number: 20110262916
    Abstract: The present invention discloses methods of determining the RhD genotype of subject. In particular, the invention provides a non-invasive method of determining fetal RhD genotype from a maternal biological sample containing fetal cells. The invention also provides novel probes and primers useful in the described methods. Kits and mixtures comprising the novel probes and primers are also disclosed.
    Type: Application
    Filed: July 17, 2009
    Publication date: October 27, 2011
    Inventors: Wen-Hua Fan, Roger Tim, Karena Kosco, Ram Bhatt
  • NON-INVASIVE ISOLATION OF FETAL NUCLEIC ACID
    Publication number: 20110143340
    Abstract: The present invention provides compositions comprising a solution of a compound useful for lysing biological cells and methods for using the compositions to lyse biological cells and to isolate nucleic acid.
    Type: Application
    Filed: October 30, 2008
    Publication date: June 16, 2011
    Applicant: BIOCEPT, INC.
    Inventors: Wen-Hua Fan, Irene Yasuda, Karena Kosco, Ram Bhatt