Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Abstract: The present disclosure provides a medical grade nanofibrillar cellulose hydrogel comprising plant-based chemically and enzymatically unmodified nanofibrillar cellulose hydrogel having a concentration of the nanofibrillar cellulose in the range of 1.4-3.4% by weight, the nanofibrillar cellulose having a number-average diameter of fibrils and/or fibril bundles of 100 nm or less, and a storage modulus in the range of 1-35 Pa. The present disclosure also provides a method for treating a subject in need of treatment of body with implantable material, and a method for manufacturing medical grade nanofibrillar cellulose hydrogel.

Abstract: The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).

Abstract: The present application relates to a method for preparing a medical product, the method comprising providing an aqueous dispersion of nanofibrillar cellulose, providing a nonwoven fabric, immersing the nonwoven fabric in the aqueous dispersion of nanofibrillar cellulose to form a coating on the nonwoven fabric, passing the immersed nonwoven fabric through a prefined gap to define the thickness of the coating on the immersed nonwoven fabric without pressing, and dewatering the immersed nonwoven fabric, to obtain the medical product. The present application also relates to a medical product comprising a supporting layer and an absorbent layer, wherein the supporting layer comprises a nonwoven fabric, and the absorbent layer comprises unpressed nanofibrillar cellulose having an average fibril diameter of 200 nm or less, wherein the absorbent layer is coating the supporting layer.

Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the content of nanofibrillar cellulose in the hydrogel is in the range of 1-3.5% (w/w), and the nanofibrillar cellulose comprises anionic nanofibrillar cellulose having an average fibril diameter of 200 nm or less, and to a method for preparing thereof. The present application also relates to the medical hydrogel for use for inducing vascularization in wounds and/or for treating deep wounds of dermis and/or below tissue.

Abstract: The present application provides a method for preparing a medical product for covering tissue, the method comprising providing nanofibrillar cellulose, providing a bioactive molecule, and covalently bonding the bioactive molecule to the nanofibrillar cellulose. The present application also provides a medical product for covering tissue comprising a bioactive molecule covalently bound to nanofibrillar cellulose.

Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa·s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.

Abstract: The present application provides a medical multi-layer product comprising a layer comprising nanofibrillar cellulose, and a layer of gauze. The present application also provides a medical product comprising the medical multi-layer product, and a cosmetic product comprising the medical multi-layer product. The present application also provides a method for preparing a medical multi-layer product, the method comprising providing a filter, providing a dispersion comprising nanofibrillar cellulose, providing a gauze, applying the dispersion onto the filter, applying the gauze onto the dispersion, and dewatering the structure through the filter to obtain the medical multi-layer product.

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Abstract: The present application provides a medical multi-layer product comprising a layer comprising nanofibrillar cellulose, and a layer of gauze. The present application also provides a medical product comprising the medical multi-layer product, and a cosmetic product comprising the medical multi-layer product. The present application also provides a method for preparing a medical multi-layer product, the method comprising providing a filter, providing a dispersion comprising nanofibrillar cellulose, providing a gauze, applying the dispersion onto the filter, applying the gauze onto the dispersion, and dewatering the structure through the filter to obtain the medical multi-layer product.

Abstract: The present application provides a method for preparing a medical product for covering tissue, the method comprising providing nanofibrillar cellulose, providing a bioactive molecule, and covalently bonding the bioactive molecule to the nanofibrillar cellulose. The present application also provides a medical product for covering tissue comprising a bioactive molecule covalently bound to nanofibrillar cellulose.

Abstract: The present application provides a method for preparing nanofibrillar cellulose product, the method comprising providing nanofibrillar cellulose, providing multivalent cations, contacting the nanofibrillar cellulose with the multivalent cations, and allowing reacting for a period of time to obtain cross-linked nanofibrillar cellulose product. The present application also provides a nanofibrillar cellulose product comprising nanofibrillar cellulose and multivalent cations, wherein the nanofibrillar cellulose is crosslinked by the multivalent cations.

Abstract: The present application relates to a method for preparing a medical product, the method comprising providing an aqueous dispersion of nanofibrillar cellulose, providing a nonwoven fabric, immersing the nonwoven fabric in the aqueous dispersion of nanofibrillar cellulose to form a coating on the nonwoven fabric, passing the immersed nonwoven fabric through a prefined gap to define the thickness of the coating on the immersed nonwoven fabric without pressing, and dewatering the immersed nonwoven fabric, to obtain the medical product. The present application also relates to a medical product comprising a supporting layer and an absorbent layer, wherein the supporting layer comprises a nonwoven fabric, and the absorbent layer comprises unpressed nanofibrillar cellulose having an average fibril diameter of 200 nm or less, wherein the absorbent layer is coating the supporting layer.

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Abstract: A medical hydrogel includes nanofibrillar cellulose, wherein the content of nanofibrillar cellulose in the hydrogel is in the range of 1-3.5% (w/w), and the nanofibrillar cellulose includes anionic nanofibrillar cellulose having an average fibril diameter of 200 nm or less. The medical hydrogel can be used for inducing vascularization in wounds and/or for treating deep wounds of dermis and/or below tissue.

Abstract: The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).

Abstract: The present disclosure relates to method for drying cell-free tissue extract in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cell-free tissue extract comprising a mixture of bioactive substances, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the cell-free tissue extract, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a cell-free tissue extract in the dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a dried hydrogel comprising nanofibrillar cellulose, cell-free tissue extract comprising a mixture of bioactive substances, polyethylene glycol and trehalose, wherein the moisture content of the dried hydrogel is 10% (w/w) or less.

Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa·s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.

Abstract: The invention relates to a method for manufacturing a composite product comprising organic natural fiber material and matrix material, wherein the method comprises mixing the organic natural fiber material with the matrix material in a primary mixing stage to form a mixture. The primary mixing stage comprises a contacting step in which the organic natural fiber material comes in contact with the matrix material that is at least partly in a form of melt, and compression ratio of the organic natural fiber material is less than 8. The method further comprises forming a composite product comprising the mixture. Further, the invention relates to a composite product, a use of the composite product, and a system for manufacturing a composite product.