Patents by Inventor Karim Ghani

Karim Ghani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-titer retroviral packaging cells
    Patent number: 8034335
    Abstract: The present invention relates to non-replicative recombinant retrovirus packaging cells able to grow in suspension in a serum-free medium. In particular, the present invention relates to a human embryonic 293SF-based cell line stably expressing gag and pol gene products from the murine Moloney leukemia virus (MLV) and either the feline RD114 env gene, the gibbon ape leukemia virus (GLV) env gene, or the amphotropic 4070Aenv gene. This particular combination allows the production of high titer of non-replicative retrovirus pseudotyped and prevents the recombination of plasmids. The recombinant retroviruses produced from these cells are safer and easier to produce for clinical use in gene therapy.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: October 11, 2011
    Assignee: Universite Laval
    Inventors: Manuel Caruso, Karim Ghani
  • HIGH-TITER RETROVIRAL PACKAGING CELLS
    Publication number: 20090098648
    Abstract: The present invention relates to non-replicative recombinant retrovirus packaging cells able to grow in suspension in a serum-free medium. In particular, the present invention relates to a human embryonic 293SF-based cell line stably expressing gag and pol gene products from the murine Moloney leukemia virus (MLV) and either the feline RD114 env gene, the gibbon ape leukemia virus (GLV) env gene, or the amphotropic 4070Aenv gene. This particular combination allows the production of high titer of non-replicative retrovirus pseudotyped and prevents the recombination of plasmids. The recombinant retroviruses produced from these cells are safer and easier to produce for clinical use in gene therapy.
    Type: Application
    Filed: April 26, 2007
    Publication date: April 16, 2009
    Inventors: Manuel Caruso, Karim Ghani
  • High-titer retroviral packaging cells
    Publication number: 20060270042
    Abstract: The present invention relates to non-replicative recombinant retrovirus packaging cells able to grow in suspension in a serum-free medium. In particular, the present invention relates to a human embryonic 293SF-based cell line stably expressing gag and pol gene products from the murine Moloney leukemia virus (MLV) and the feline RD114 env gene. This particular combination allows the production of high titer of non-replicative retrovirus pseudotyped and prevents the recombination of plasmids. The recombinant retroviruses produced from these cells are safer and easier to produce for clinical use in gene therapy.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 30, 2006
    Inventors: Manuel Caruso, Vincent Roy, Marie-Christine Caron, Karim Ghani