Abstract: A method of classifying a cancerous tumor is described and comprises the steps of: screening a set of targetable events within a tumor, determining a profile for tumor, and classifying the tumor based on the variant profile of the tumor. More specifically, the tumor is defined and classified based on targetable events; histology and disease stage are not considered. The method will result in greater numbers of samples for clinical studies and better, more accurate combinatorial approaches for treatment. This method overcomes the biases of traditional cancer classification schemes, and advances personalized medicine in solid tumor cancers.