Abstract: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents.

Abstract: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents.

Abstract: The present invention relates to a system for detecting molecular associations. In particular, the present invention relates to a multi-component detection system comprising: i). a first agent comprising a first interacting group coupled directly or indirectly to a first tag, which first tag emits light of a first wavelength upon activation by a substrate or energy source, which produces a first activated tag; ii). a second agent comprising a second interacting group coupled directly or indirectly to a second tag, which second tag can accept the energy from the first tag when the first and second interacting groups are associated and an appropriate substrate or energy source for the first tag is present thereby producing a second activated tag that emits light of a second wavelength; iii).