Patents by Inventor Karin Aase

Karin Aase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Platelet-derived growth factor D, DNA coding therefor, and uses thereof
    Publication number: 20070042413
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: August 22, 2006
    Publication date: February 22, 2007
    Applicants: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
  • Platelet-derived growth factor D, DNA coding therefor, and uses thereof
    Patent number: 7148037
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: December 12, 2006
    Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
  • Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof
    Patent number: 7034200
    Abstract: Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: April 25, 2006
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Ulf Eriksson, Xuri Li, Annica Ponten, Karin Aase, Hong Li
  • Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents
    Publication number: 20050250103
    Abstract: A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.
    Type: Application
    Filed: November 13, 2003
    Publication date: November 10, 2005
    Applicant: Ludwig Institute for Cancer Research
    Inventors: Xuri Li, Karin Aase, Ulf Eriksson
  • Platelet-derived growth factor D
    Patent number: 6706687
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of growth factors, is described, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: March 16, 2004
    Assignees: Ludwig Institute for Cancer Research, Helsinki University
    Inventors: Ulf Eriksson, Karin Aase, Xuri Lee, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
  • Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents
    Patent number: 6670125
    Abstract: A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: December 30, 2003
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Xuri Li, Karin Aase, Ulf Eriksson
  • Platelet-derived growth factor C, DNA coding therefor, and uses thereof
    Publication number: 20020164687
    Abstract: PDGF-C, a new member of the PDGF/VEGF family of growth factors, is described, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: May 10, 2001
    Publication date: November 7, 2002
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin, Christer Betsholtz
  • Platelet-derived growth factor D, DNA coding therefor, and uses thereof
    Publication number: 20020164710
    Abstract: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.
    Type: Application
    Filed: March 4, 2002
    Publication date: November 7, 2002
    Inventors: Ulf Eriksson, Karin Aase, Xuri Li, Annica Ponten, Marko Uutela, Kari Alitalo, Arne Oestman, Carl-Henrik Heldin
  • Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents
    Publication number: 20020081637
    Abstract: A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.
    Type: Application
    Filed: May 17, 2001
    Publication date: June 27, 2002
    Inventors: Xuri Li, Karin Aase, Ulf Eriksson
  • Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof
    Publication number: 20020049987
    Abstract: Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.
    Type: Application
    Filed: March 28, 2001
    Publication date: April 25, 2002
    Inventors: Ulf Eriksson, Xuri Li, Annica Ponten, Karin Aase, Hong Li
  • Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B DNA) and uses thereof
    Patent number: 6262337
    Abstract: Transgenic animals containing recombinant DNA with modified nucleotide sequence from the vascular endothelial growth factor B (VEGF-B) gene, cells and methods for producing such animals, and methods of using them to assay substances for VEGF-B-like activity.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: July 17, 2001
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Gabriel von Euler, Karin Aase, Christer Betsholtz, Ulf Eriksson, Milos Pekny, Samuel Gebre-Medhin, Xuri Li