Patents by Inventor Karin Büttner
Karin Büttner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200182863Abstract: The present invention generally relates to the field of Fluorescence Quenching Immunoassays. Specifically, the invention provides novel antibody conjugates suitable for use in Discrete Fluorescence Quenching Displacement Immunoassays and methods for producing these antibody conjugates. The invention further relates to the use the novel antibody conjugates, and a kit comprising the same.Type: ApplicationFiled: August 8, 2018Publication date: June 11, 2020Applicant: LIFE SCIENCE INKUBATOR SACHSEN GMBH & CO. KGInventors: Karin BUETTNER, Tom STUECKEMANN
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Patent number: 10098750Abstract: An intervertebral disk prostheses for the total replacement of an intervertebral disk of the lumbar and cervical spine has an upper plate having upwardly projecting formations anchoring it to an upper vertebra on its upper face and a concavity on its inner face surrounded by an edge. A lower plate is provided with downwardly projecting formations anchoring it to a lower vertebra on its lower face and a flat inner face surrounding a groove extending front-to-back. A middle plate between the upper and lower plate has on its upper face a convexity that is identically or differently shaped to the concavity on the inner face of the upper plate and a ridge extending front-to-back surrounded by a flat lower face of the middle plate. The ridge has flanks and the groove houses the ridge of the middle plate and permits the ridge to slide front-to-back in the groove.Type: GrantFiled: August 29, 2014Date of Patent: October 16, 2018Inventors: Karin Buettner-Janz, Nelli Ruediger
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Patent number: 9976135Abstract: The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue E64 is replaced with an amino acid residue comprising a positively charged side chain, amino acid residue K123 is replaced with an amino acid residue comprising an aliphatic side chain and amino acid residues Y139 and D147 are replaced with a glutamine or asparagine residue, and wherein said variant is further characterized in that: an amino acid residue selected from E16, E17 and E142 is replaced with an amino acid residue comprising an aliphatic side chain, and/or amino acid residue N18 is replaced with a histidine residue, and/or amino acid residue R107 is replaced with a lysine residue, and/or amino acid residue D138 is replaced with an amino acid residue comprising a positively charged side chain, and wherein said variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1.Type: GrantFiled: September 25, 2014Date of Patent: May 22, 2018Assignee: LIFE SCIENCE INKUBATOR GMBHInventors: Karin Büttner, Agneta Prasse, Thole Zuchner
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Patent number: 9308100Abstract: The invention relates to an intervertebral disc prosthesis for the total replacement of the intervertebral disc within the lumbar and cervical spine. For a two part as well as for a three part intervertebral disc prosthesis, according to the invention, in accordance to the design of the edges of the sliding partners, there are aspects for at least one of the sliding partners, in which there is an wavelike design of the edge, as the respectively different high edge regions preferably fluently merge.Type: GrantFiled: April 18, 2006Date of Patent: April 12, 2016Inventors: Karin Buettner-Janz, Eiko Buettner
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Patent number: 9265617Abstract: The present invention relates to an intervertebral disc prosthesis for the total replacement of an intervertebral disc of the cervical or lumbar spine. The prosthesis provided by the invention is intended for coupled physiological motion within the disc space. The design of the disclosed prosthesis is based on an inlay positioned within the articulation area of two adjacent sliding partners and provides the advantage of comprising a ball and socket shaped articulation area, which enables limitation of rotation around the sagittal, frontal and longitudinal axis. The inlay is protected against luxation due to its position within a recess of one of the adjacent sliding partners. An additional protuberance going through the inlay is protecting against luxation of the adjacent sliding.Type: GrantFiled: October 6, 2010Date of Patent: February 23, 2016Inventors: Karin Buettner-Janz, Eiko Buettner
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Publication number: 20140371856Abstract: An intervertebral disk prostheses for the total replacement of an intervertebral disk of the lumbar and cervical spine has an upper plate having upwardly projecting formations anchoring it to an upper vertebra on its upper face and a concavity on its inner face surrounded by an edge. A lower plate is provided with downwardly projecting formations anchoring it to a lower vertebra on its lower face and a flat inner face surrounding a groove extending front-to-back. A middle plate between the upper and lower plate has on its upper face a convexity that is identically or differently shaped to the concavity on the inner face of the upper plate and a ridge extending front-to-back surrounded by a flat lower face of the middle plate. The ridge has flanks and the groove houses the ridge of the middle plate and permits the ridge to slide front-to-back in the groove.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Inventors: Karin Buettner-Janz, Nelli Ruediger
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Patent number: 8888851Abstract: An intervertebral disc prosthesis for the total replacement of an intervertebral disc within the lumbar and cervical spine is disclosed. The intervertebral disc prosthesis comprises articulating sliding partners, wherein the upper sliding partner is adapted for a firm assembly to an upper vertebral body and the lower sliding partner is adapted for a firm assembly to a lower vertebral body. The functional two part design provides a dorsoventral motion and in the transversal plane a rotational motion around a fictitious vertical axis as a result of a laterolaterally aimed, transversally arched, ventrally curved cylindrical convexity and corresponding concavity but prevents an inclination of the sliding partners in a lateral direction. According to the invention, the intervertebral disk prostheses are suited for implantation from lateral and ventrolateral, particularly in revision surgeries.Type: GrantFiled: August 15, 2011Date of Patent: November 18, 2014Inventor: Karin Buettner-Janz
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Publication number: 20130184828Abstract: The present invention relates to an intervertebral disc prosthesis for the total replacement of an intervertebral disc of the cervical or lumbar spine. The prosthesis provided by the invention is intended for coupled physiological motion within the disc space. The design of the disclosed prosthesis is based on an inlay positioned within the articulation area of two adjacent sliding partners and provides the advantage of comprising a ball and socket shaped articulation area, which enables limitation of rotation around the sagittal, frontal and longitudinal axis. The inlay is protected against luxation due to its position within a recess of one of the adjacent sliding partners.Type: ApplicationFiled: October 6, 2010Publication date: July 18, 2013Inventors: Karin Buettner-Janz, Eiko Buettner
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Patent number: 8403989Abstract: Disclosed is an intervertebral disc prosthesis for the total replacement of a natural intervertebral disc within the lumbar and cervical spine, comprising of articulating sliding partners. The upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body. At least one sliding surface is between two sliding partners. Two- and three-part functional designs are planned and both having in common, that, as a result of the shape of the articulating surface(s), the laterolateral and dorsoventral motion amplitudes differ. The resulting angles including the rotation around a fictitious vertical axis can be defined to a desired extent.Type: GrantFiled: February 2, 2010Date of Patent: March 26, 2013Inventors: Karin Buettner-Janz, Eiko Buettner
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Publication number: 20120296429Abstract: An intervertebral disk prostheses for the total replacement of an intervertebral disk of the lumbar and cervical spine has an upper plate having upwardly projecting formations anchoring it to an upper vertebra on its upper face and a concavity on its inner face surrounded by an edge. A lower plate is provided with downwardly projecting formations anchoring it to a lower vertebra on its lower face and a flat inner face surrounding a groove extending front-to-back. A middle plate between the upper and lower plate has on its upper face a convexity that is identically or differently shaped to the concavity on the inner face of the upper plate and a ridge extending front-to-back surrounded by a flat lower face of the middle plate. The ridge has flanks and the groove houses the ridge of the middle plate and permits the ridge to slide front-to-back in the groove.Type: ApplicationFiled: February 3, 2012Publication date: November 22, 2012Inventors: Nelli WIEDENBECK, Karin BUETTNER-JANZ
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Publication number: 20120089230Abstract: An intervertebral disc prosthesis for the total replacement of a intervertebral disc within the lumbar and cervical spine is disclosed. The intervertebral disc prosthesis comprises articulating sliding partners and at least one sliding surface that is between two sliding partners. Two part designs are described in which only a dorsoventral- and rotational movement is possible as a result of laterolaterally aimed, transversally arched, ventrally curved cylindrical convexity(ies) and corresponding concavity(ies), without an inclination of the sliding partners in a lateral direction. In a further design, the cylindrical articulation surfaces have no curvature, enabling a motion of the sliding partners in only a ventrodorsal direction. According to the invention, the intervertebral disk prostheses are suited for implantation from lateral and ventrolateral, particularly in revision surgeries.Type: ApplicationFiled: August 15, 2011Publication date: April 12, 2012Inventor: Karin Büttner-Janz
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Patent number: 8016888Abstract: An intervertebral disc prosthesis for the total replacement of a intervertebral disc within the lumbar and cervical spine is disclosed. The intervertebral disc prosthesis comprises articulating sliding partners, wherein the upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body and at least one sliding surface that is between two sliding partners. Functional two- and three part designs are planned and both prostheses have in common, that only a dorsoventral- and rotation movement is possible as a result of laterolaterally aimed, transversally arched, ventrally curved cylindrical convexity(ies) and corresponding concavity(ies), however without an inclination of the sliding partners in a lateral direction. In a further design, the cylindrical articulation surfaces have no curvature, enabling a motion of the sliding partners in only a ventrodorsal direction.Type: GrantFiled: April 18, 2006Date of Patent: September 13, 2011Inventor: Karin Buettner-Janz
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Patent number: 7833273Abstract: Disclosed is an intervertebral disc prosthesis for the total replacement of a natural intervertebral disc within the lumbar and cervical spine, comprising of articulating sliding partners. The upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body. At least one sliding surface is between two sliding partners. Two- and three-part functional designs are planned and both having in common, that, as a result of the shape of the articulating surface(s), the laterolateral and dorsoventral motion amplitudes differ. The resulting angles including the rotation around a fictitious vertical axis can be defined to a desired extent.Type: GrantFiled: April 18, 2006Date of Patent: November 16, 2010Inventors: Karin Buettner-Janz, Eiko Büttner
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Publication number: 20100137992Abstract: Disclosed is an intervertebral disc prosthesis for the total replacement of a natural intervertebral disc within the lumbar and cervical spine, comprising of articulating sliding partners. The upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body. At least one sliding surface is between two sliding partners. Two- and three-part functional designs are planned and both having in common, that, as a result of the shape of the articulating surface(s), the laterolateral and dorsoventral motion amplitudes differ. The resulting angles including the rotation around a fictitious vertical axis can be defined to a desired extent.Type: ApplicationFiled: February 2, 2010Publication date: June 3, 2010Inventors: Karin Büttner-Janz, Eiko Büttner
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Publication number: 20060241772Abstract: The invention relates to an intervertebral disc prosthesis for the total replacement of a natural intervertebral disc within the lumbar and cervical spine, comprising of articulating sliding partners, where the upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body and at least one sliding surface that is between two sliding partners. According to the invention there are two- and three-part functional designs planned and both prostheses have in common, that as a result of the shaping of the articulating surface(s), the laterolateral and dorsoventral motion amplitudes differ in size and the resulting angles including the rotation around a fictitious vertical axis can be defined in a desired extent.Type: ApplicationFiled: April 18, 2006Publication date: October 26, 2006Inventors: Karin Buettner-Janz, Eiko Buettner
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Publication number: 20060235528Abstract: The invention relates to a sliding core and an intervertebral disc prosthesis for the compensation of angles between vertebral endplates, for the preservation or improvement of function of a motion segment of the lumbar or cervical spine. A sliding core, according to the invention, for functional two- or three part intervertebral disc prostheses, is intended to ascertain a compensation, for the correction or preservation of angles within an intervertebral space. By this, it is possible not to have to remove implanted prosthetic plates from their assembly to vertebral bodies. According to the invention, functional two- and three part intervertebral disc prostheses with an asymmetrically angled sliding core are also planned. Concomitantly, upper and lower sliding partner of a three component prosthesis as well as the two sliding partners of a two part prosthesis function as endplates, which have means for a firm assembly to an upper and lower vertebral body.Type: ApplicationFiled: April 18, 2006Publication date: October 19, 2006Inventor: Karin Buettner-Janz
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Publication number: 20060235527Abstract: The invention relates to an intervertebral disc prosthesis for the total replacement of the intervertebral disc within the lumbar and cervical spine. For a two part as well as for a three part intervertebral disc prosthesis, according to the invention, in accordance to the design of the edges of the sliding partners, there are aspects for at least one of the sliding partners, in which there is an wavelike design of the edge, as the respectively differently high edge regions preferably fluently merge.Type: ApplicationFiled: April 18, 2006Publication date: October 19, 2006Inventors: Karin Buettner-Janz, Eiko Buettner
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Publication number: 20060235531Abstract: The invention relates to an intervertebral disc prosthesis for the total replacement of a natural intervertebral disc within the lumbar and cervical spine, comprising articulating sliding partners, where the upper sliding partner has means for a firm assembly to an upper vertebral body and the lower sliding partner has means for a firm assembly to a lower vertebral body and at least one sliding surface that is between two sliding partners. According to the invention, functional two- and three part designs are planned and both prostheses have in common, that only a dorsoventral- and rotation movement is possible as a result of laterolaterally aimed, transversally arched, ventrally curved cylindrical convexity(ies) and corresponding concavity(ies), however without an inclination of the sliding partners in a lateral direction. In a further design, the cylindrical articulation surfaces are un-curved, enabling a motion of the sliding partners in only a ventrodorsal direction.Type: ApplicationFiled: April 18, 2006Publication date: October 19, 2006Inventor: Karin Buettner-Janz
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Patent number: 4759766Abstract: An intervertebral disc endoprothesis comprises two symmetrical, concave end plates with an intermediate convex spacing piece. The end plates and the spacing piece have a plane guide rim. The end plates either have an edge shoulder or an annular groove for a toroid provided on the spacing piece. Alternatively, the intervertebral disc endoprothesis comprises two asymmetric end plates and a spacing piece, however, the two areas of movement are offset by 90.degree. in relation to each other and are partial surfaces of a cylinder. In the third variation, the two symmetrical end plates are convex, the spacing piece is cylindrical as well as concave at the two ends and has a durable cover.Type: GrantFiled: September 9, 1987Date of Patent: July 26, 1988Assignee: Humboldt-Universitaet zu BerlinInventors: Karin Buettner-Janz, Bernd Derr, Klaus-Peter Erkel, Hans-Joachim Helisch, Kurt Schellnack, Roland Schumann