Abstract: Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy.

Abstract: The invention relates to antibacterial amide macrocycles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular of bacterial infections.

Abstract: The invention relates to antibacterial amide-macrocycles of formula (I), in which R26 represents hydrogen, halogen, amino or methyl, R7 represents a group of formula (II), (III), (IV) or (V), whereby R1 represents hydrogen or hydroxy and * is the linkage site to the carbon atom, R2 represents hydrogen or methyl and methods for their production, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular of bacterial infections.

Abstract: The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

Abstract: A method and a circuit arrangement for generating setting signals for signal generators of a traffic signal system, particularly of a street traffic signal system, upon employment of indications of time intervals between mutually hostile traffic flows contained in a time interval matrix are discussed. The time intervals are read from the time interval matrix for each entry signal group and subtracted from the greatest time interval value which greatest time interval value is reduced in value in cyclical succession. When this value is reduced to zero or, respectively, when a zero difference is determined in the course of the difference formations, then appropriate setting signals for the signal generators of the traffic signal system are emitted.

Abstract: A method and apparatus for securing the intermediate protective time periods at an intersection in a street traffic signal system to provide adequate safety protection between respective traffic flows, in which, following the end of the duration of the green light time period of individual signal of the respective traffic flows to be independently controlled, the time elapsing thereafter, representing an actual time value, is totaled and compared with predetermined theoretical protective time values for traffic flows antagonistic to the green light signal to be connected, and upon attaining and/or exceeding the predetermined values, an associated connect command to said last-mentioned green light signal is released, and adding, at intervals somewhat smaller than those corresponding to the time rhythm of the traffic signal, all of said theoretical time values, thus forming an additional actual total time value, which is compared with a theoretical total time value therefor, and in the event an error is ascerta