Abstract: A syringe assembly includes a barrel having a chamber for retaining fluid. The barrel has an open proximal end, a distal end and an elongated tip extending from the distal end having a passageway therethrough in fluid communication with the chamber. The tip has a diameter at its distal end of less than about 3.8 mm and a side wall tapered proximally outwardly at a taper of from 4% to 8%. A plunger rod includes an elongated body portion having a proximal end, a distal end and a stopper at the distal end. The stopper is slidably positioned in fluid-tight engagement in the barrel. An elongated projection extending distally from the distal end of the plunger rod is shaped to fit within the passageway of the elongated tip. Structure is provided for preventing proximal motion of the plunger rod with respect to the barrel after distal motion of the stopper to expel fluid through the passageway.