Patents by Inventor Karin Hayashi

Karin Hayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Construction of protein-responsive shRNA/RNAi control system using RNP motif
    Patent number: 8871437
    Abstract: An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence; a passenger strand which forms a duplex with the guide strand; and a linker strand which links the guide strand and the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. The present invention also provides an RNAi control system comprising: the shRNA; and an RNP-derived protein which specifically binds to a protein-binding motif sequence in the shRNA.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: October 28, 2014
    Assignee: Japan Science and Technology Agency
    Inventors: Tan Inoue, Hirohide Saito, Shunichi Kashida, Karin Hayashi
  • Construction of Protein-Responsive shRNA/RNAi Control System Using RNP Motif
    Publication number: 20110263026
    Abstract: An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence; a passenger strand which forms a duplex with the guide strand; and a linker strand which links the guide strand and the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. The present invention also provides an RNAi control system comprising: the shRNA; and an RNP-derived protein which specifically binds to a protein-binding motif sequence in the shRNA.
    Type: Application
    Filed: December 9, 2009
    Publication date: October 27, 2011
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Tan Inoue, Hirohide Saito, Shunichi Kashida, Karin Hayashi