Patents by Inventor Karin Henderika Maria Bessembinder

Karin Henderika Maria Bessembinder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing statin precursor
    Patent number: 10246423
    Abstract: The present invention relates to a process for preparing a statin precursor, which process comprises a first reaction step, wherein a hydroxy-pyrimidine-carbonitrile is reacted with an organic sulfonyl halide to form the sulfonate-pyrimidine-carbonitrile; a second reaction step, wherein the sulfonate-pyrimidine-carbonitrile is reacted with N-methylmethane sulfonamide to form a pyrimidinyl-sulfonamide; and optionally a third reaction step, wherein the pyrimidinyl-sulfonamide is reacted with a reducing agent. All steps are conducted in toluene as the main solvent.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: April 2, 2019
    Assignee: Centrient Pharmaceuticals Netherlands B.V.
    Inventors: Ben De Lange, Karin Henderika Maria Bessembinder, Dennis Heemskerk
  • IMPROVED PROCESS FOR PREPARING A STATIN PRECURSOR
    Publication number: 20180111906
    Abstract: The present invention relates to a process comprising reacting p-fluorobenzaldehyde, 4-methyl-3-oxopentanenitrile and urea in a first reaction mixture comprising a first organic solvent, thereby obtaining an intermediate mixture comprising an oxo-pyrimidine-carbonitrile; and oxidizing the oxo-pyrimidine-carbonitrile by contacting the intermediate mixture or organic extract with an organic hydroperoxide, thereby obtaining a hydroxyl-pyrimidine carbonitrile.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 26, 2018
    Inventors: Ben De Lange, Karin Henderika Maria Bessembinder, Dennis Heemskerk
  • IMPROVED PROCESS FOR PREPARING STATIN PRECURSOR
    Publication number: 20180016241
    Abstract: The present invention relates to a process for preparing a statin precursor, which process comprises a first reaction step, wherein a hydroxy-pyrimidine-carbonitrile is reacted with an organic sulfonyl halide to form the sulfonate-pyrimidine-carbonitrile; a second reaction step, wherein the sulfonate-pyrimidine-carbonitrile is reacted with N-methylmethane sulfonamide to form a pyrimidinyl-sulfonamide; and optionally a third reaction step, wherein the pyrimidinyl-sulfonamide is reacted with a reducing agent. All steps are conducted in toluene as the main solvent.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 18, 2018
    Inventors: Ben De Lange, Karin Henderika Maria Bessembinder, Dennis Heemskerk
  • Amine salts of pitavastatin and rosuvastatin
    Patent number: 9630906
    Abstract: The present invention relates to unsaturated amine salts of HMG-CoA reductase inhibitors, to a method of producing said amine salts and to the use of said amine salts in the production of pharmaceutically acceptable salts of HMG-CoA reductase inhibitors.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 25, 2017
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Ben De Lange, Henricus Leonardus Marie Elsenberg, Karin Henderika Maria Bessembinder
  • AMINE SALTS OF PITAVASTATIN AND ROSUVASTATIN
    Publication number: 20160052864
    Abstract: The present invention relates to unsaturated amine salts of HMG-CoA reductase inhibitors, to a method of producing said amine salts and to the use of said amine salts in the production of pharmaceutically acceptable salts of HMG-CoA reductase inhibitors.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 25, 2016
    Inventors: Ben DE LANGE, Henricus Leonardus Marie ELSENBERG, Karin Henderika Maria BESSEMBINDER
  • Process for the preparation of a thioprecursor for statins
    Patent number: 9260423
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: February 16, 2016
    Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • Process for the preparation of statins in the presence of base
    Patent number: 9126975
    Abstract: The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: September 8, 2015
    Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
    Inventors: Karin Henderika Maria Bessembinder, Dennis Heemskerk, Ben De Lange
  • Process for the preparation of a statin precursor
    Patent number: 8987478
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: March 24, 2015
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR
    Publication number: 20140357864
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Application
    Filed: December 6, 2012
    Publication date: December 4, 2014
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS
    Publication number: 20140343292
    Abstract: The present invention relates to a process for the preparation of a precursor for the synthesis of hexanoic acid derived statins and to the use of said precursor in the manufacture of a medicament.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 20, 2014
    Inventors: Ben De Lange, Dennis Heemskerk, Karin Henderika Maria Bessembinder
  • PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE
    Publication number: 20130296561
    Abstract: The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.
    Type: Application
    Filed: January 13, 2012
    Publication date: November 7, 2013
    Applicant: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
    Inventors: Karin Henderika Maria Bessembinder, Dennis Heemskerk, Ben De Lange