Patents by Inventor Karin J. van Charldorp

Karin J. van Charldorp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,4-dehydropiperidine derivatives
    Patent number: 5409940
    Abstract: The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms;Y is a group of the general formula 2 ##STR2## wherein R.sub.2 is a group of the formula --(CH.sub.2).sub.n --C(.dbd.X)--NR.sub.3 R.sub.4, --(CH.sub.2).sub.n --SO.sub.2 --NR.sub.3 R.sub.4, --(CH.sub.2).sub.n --NR.sub.5 --C(.dbd.X)--R.sub.6 or --(CH.sub.2).sub.n --NR.sub.5 --SO.sub.2 --R.sub.6, wherein R.sub.3, R.sub.4 and R.sub.5 independent of each other represent hydrogen or alkyl (1-3C), R.sub.6 is alkyl (1-3C), X represents O or S; n is 0-4, andR is hydrogen or alkyl (1-3C).These compounds have interesting serotonin-1-like (partial) agonistic activity and can be used for the treatment of migraine.
    Type: Grant
    Filed: October 19, 1993
    Date of Patent: April 25, 1995
    Assignee: Duphar International Research B.V.
    Inventors: Antonius Hulkenberg, Karin J. van Charldorp, Rolf van Hes, Ineke van Wijngaarden