Patents by Inventor Karin Jooss

Karin Jooss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SARS-COV-2 VACCINES
    Publication number: 20250121052
    Abstract: Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: May 8, 2024
    Publication date: April 17, 2025
    Inventors: Leonid Gitlin, Karin Jooss, Sue-Jean Hong, Ciaran Daniel Scallan, Amy Rachel Rappaport, Christine Denise Palmer, Minh Duc Cao
  • SELF-AMPLIFYING RNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250108105
    Abstract: The present disclosure includes, among other things, RNA polynucleotide compositions that (A) include modified nucleosides; and/or (B) have been purified using a chromatography system and/or an affinity-based separation system. Methods of production and treatment related to the same are also provided.
    Type: Application
    Filed: May 8, 2024
    Publication date: April 3, 2025
    Inventors: Sue-Jean Hong, Mario Fidanza, Karin Jooss
  • IMMUNE CHECKPOINT INHIBITOR CO-EXPRESSION VECTORS
    Publication number: 20250025544
    Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: January 4, 2024
    Publication date: January 23, 2025
    Inventors: Wade Blair, Karin Jooss, Leonid Gitlin, Ciaran Daniel Scallan, Amy Rachel Rappaport, Gijsbert Grotenbreg
  • Alphavirus neoantigen vectors
    Patent number: 12109257
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: October 8, 2024
    Assignee: Gritstone Bio, Inc.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Modified adenoviruses
    Patent number: 12098383
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: September 24, 2024
    Assignee: Gritstone bio, Inc.
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • MULTIEPITOPE VACCINE CASSETTES
    Publication number: 20240285739
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: August 29, 2023
    Publication date: August 29, 2024
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • MULTI-SPECIFIC ANTIBODIES AND METHODS OF USE
    Publication number: 20240279343
    Abstract: Provided herein are multispecific antigen binding proteins that selectively bind a particular KKLC-1 (CT-83) shared antigen and CD3, as well as related methods, kits, and compositions. Included herein are multispecific antigen binding proteins with a circularized conformation.
    Type: Application
    Filed: July 12, 2023
    Publication date: August 22, 2024
    Inventors: Isaac J. Rondon, Christine Janson, Manankumar Anilkumar Shah, Karin Jooss
  • PANCORONAVIRUS VACCINES
    Publication number: 20240238412
    Abstract: Disclosed herein are vaccine compositions that include Pancorona receptor binding domain (RBD) encoding cassettes and/or MHC epitope-encoding cassettes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: March 29, 2024
    Publication date: July 18, 2024
    Inventors: Leonid Gitlin, Karin Jooss, Sue-Jean Hong, Ciaran Daniel Scallan, Amy Rachel Rappaport, Christine Denise Palmer, Minh Duc Cao, Joshua Klein
  • KRAS-NEOANTIGEN THERAPIES
    Publication number: 20240238397
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, such as in subjects with cancer that includes (1) a solid tumor expressing the KRAS-associated MHC class I neoepitope, (2) colorectal cancer (CRC), (3) non-small cell lung cancer (NSCLC), and/or (4) pancreatic ductal adenocarcinoma (PDA).
    Type: Application
    Filed: March 15, 2024
    Publication date: July 18, 2024
    Inventors: Raphael Rousseau, Karin Jooss, Christine Denise Palmer, Amy Rachel Rappaport
  • NEOANTIGEN ADJUVANT AND MAINTENANCE THERAPY
    Publication number: 20240216501
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: March 15, 2024
    Publication date: July 4, 2024
    Inventors: Raphael Rousseau, Andrew Ferguson, Karin Jooss
  • HOMOLOGOUS ADENOVIRAL VACCINATION
    Publication number: 20240093235
    Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 21, 2024
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Amy Rachel Rappaport, Christine Denise Palmer
  • VIRAL DELIVERY OF NEOANTIGENS
    Publication number: 20240067985
    Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: January 10, 2023
    Publication date: February 29, 2024
    Inventors: Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky, Gijsbert Grotenbreg
  • ENGINEERED MULTI-SPECIFIC ANTIBODIES AND RELATED METHODS OF USE AND MANUFACTURE
    Publication number: 20240059797
    Abstract: Provided herein are multispecific antigen binding proteins (ABPs). Also provided herein are multispecific ABPs that are engineered to form diabodies or stay in extended (dual scFv) conformation and methods for purifying ABPs based on avidity.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 22, 2024
    Inventors: Godfrey Jonah Anderson Rainey, Karin Jooss, Shan Liu Hwang, Gayatri Prakash, Isaac J. Rondon
  • INFECTIOUS DISEASE ANTIGENS AND VACCINES
    Publication number: 20240050550
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: October 3, 2022
    Publication date: February 15, 2024
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer
  • ALPHAVIRUS NEOANTIGEN VECTORS
    Publication number: 20240024445
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: October 11, 2022
    Publication date: January 25, 2024
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • MODIFIED ADENOVIRUSES
    Publication number: 20230407332
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Application
    Filed: January 4, 2023
    Publication date: December 21, 2023
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS
    Publication number: 20230382997
    Abstract: Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets as well as identifying one or more antigen binding proteins that bind a give n HLA-PEPTIDE target.
    Type: Application
    Filed: December 13, 2022
    Publication date: November 30, 2023
    Inventors: Karin Jooss, Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Michele Anne Busby, Joshua Michael Francis, Gijsbert Marnix Grotenbreg, Mojca Skoberne, Roman Yelensky
  • SARS-COV-2 VACCINES
    Publication number: 20230330215
    Abstract: Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Inventors: Roman Yelensky, Minh Duc Cao, Mike Zhong, Justin Helbert, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Amy Rachel Rappaport
  • ANTIGEN-ENCODING CASSETTES
    Publication number: 20230310563
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple repeats of distinct epitope-encoding sequences or having antigen-encoding nucleic acid sequences having less than 700 nucleotides and encoding multiple distinct epitope-encoding sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: October 20, 2022
    Publication date: October 5, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Multiepitope vaccine cassettes
    Patent number: 11771747
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 3, 2023
    Assignee: Gritstone Bio, Inc.
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane