Patents by Inventor Karin Jooss

Karin Jooss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alphavirus neoantigen vectors and interferon inhibitors
    Patent number: 12653883
    Abstract: Disclosed herein are vectors that include alphavirus-based expression platforms. Also disclosed are methods associated with the alphavirus-based expression platforms and co-administration of an inhibitor of Type I interferon signaling.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: June 16, 2026
    Assignee: Seattle Project Corp.
    Inventors: Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
  • Multi-specific antibodies and methods of use
    Patent number: 12643949
    Abstract: Provided herein are multispecific antigen binding proteins that selectively bind a particular KKLC-1 (CT-83) shared antigen and CD3, as well as related methods, kits, and compositions. Included herein are multispecific antigen binding proteins with a circularized conformation.
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: June 2, 2026
    Assignee: Gritstone bio, Inc.
    Inventors: Isaac J. Rondon, Christine Janson, Manankumar Anilkumar Shah, Karin Jooss
  • Antigen-binding proteins and related methods of use
    Patent number: 12630637
    Abstract: Provided herein are antigen binding proteins (ABPs) that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets and methods of treating cancers and other diseases using the disclosed ABPs.
    Type: Grant
    Filed: July 29, 2025
    Date of Patent: May 19, 2026
    Assignee: Gritstone bio, Inc.
    Inventors: Godfrey Jonah Anderson Rainey, Karin Jooss, Roman Yelensky, Wade Blair, Heungnam Kim, Christine Janson, Anne Van Abbema, Isaac J. Rondon
  • Infectious disease antigens and vaccines
    Patent number: 12616746
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: May 5, 2026
    Assignee: Seattle Project Corp.
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer
  • MULTI-SPECIFIC ANTIBODIES AND METHODS OF USE
    Publication number: 20260062487
    Abstract: Provided herein are multispecific antigen binding proteins that selectively bind a particular KKLC-1 (CT-83) shared antigen and CD3, as well as related methods, kits, and compositions. Included herein are multispecific antigen binding proteins with a circularized conformation.
    Type: Application
    Filed: July 29, 2025
    Publication date: March 5, 2026
    Inventors: Isaac J. RONDON, Christine JANSON, Manankumar Anilkumar SHAH, Karin JOOSS
  • ANTIGEN-BINDING PROTEINS AND RELATED METHODS OF USE
    Publication number: 20250353914
    Abstract: Provided herein are antigen binding proteins (ABPs) that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets and methods of treating cancers and other diseases using the disclosed ABPs.
    Type: Application
    Filed: July 29, 2025
    Publication date: November 20, 2025
    Inventors: Godfrey Jonah Anderson RAINEY, Karin JOOSS, Roman YELENSKY, Wade BLAIR, Heungnam KIM, Christine JANSON, Anne VAN ABBEMA, Isaac J. RONDON
  • EGFR VACCINE CASSETTES
    Publication number: 20250276049
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of EGFR neoepitope-encoding sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: January 24, 2025
    Publication date: September 4, 2025
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • CTA VACCINE CASSETTES
    Publication number: 20250269002
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of CTA epitope-encoding sequences or Cancer Testis Antigen (CTA)-encoding nucleic acid sequences and KRAS-encoding nucleic acid sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: February 3, 2025
    Publication date: August 28, 2025
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Melissa Rotunno, Monica Lane
  • VIRAL DELIVERY OF NEOANTIGENS
    Publication number: 20250270589
    Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: May 6, 2025
    Publication date: August 28, 2025
    Inventors: Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky, Gijsbert Grotenbreg
  • LOW-DOSE NEOANTIGEN VACCINE THERAPY
    Publication number: 20250255946
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: September 20, 2024
    Publication date: August 14, 2025
    Inventors: Karin Jooss, Brian Chauder, Andrew Ferguson
  • ALPHAVIRUS ANTIGEN VECTORS
    Publication number: 20250249084
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: September 11, 2024
    Publication date: August 7, 2025
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • MODIFIED ADENOVIRUSES
    Publication number: 20250236884
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Application
    Filed: September 4, 2024
    Publication date: July 24, 2025
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • SARS-COV-2 VACCINES
    Publication number: 20250121052
    Abstract: Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: May 8, 2024
    Publication date: April 17, 2025
    Inventors: Leonid Gitlin, Karin Jooss, Sue-Jean Hong, Ciaran Daniel Scallan, Amy Rachel Rappaport, Christine Denise Palmer, Minh Duc Cao
  • SELF-AMPLIFYING RNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250108105
    Abstract: The present disclosure includes, among other things, RNA polynucleotide compositions that (A) include modified nucleosides; and/or (B) have been purified using a chromatography system and/or an affinity-based separation system. Methods of production and treatment related to the same are also provided.
    Type: Application
    Filed: May 8, 2024
    Publication date: April 3, 2025
    Inventors: Sue-Jean Hong, Mario Fidanza, Karin Jooss
  • IMMUNE CHECKPOINT INHIBITOR CO-EXPRESSION VECTORS
    Publication number: 20250025544
    Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: January 4, 2024
    Publication date: January 23, 2025
    Inventors: Wade Blair, Karin Jooss, Leonid Gitlin, Ciaran Daniel Scallan, Amy Rachel Rappaport, Gijsbert Grotenbreg
  • Alphavirus neoantigen vectors
    Patent number: 12109257
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: October 8, 2024
    Assignee: Gritstone Bio, Inc.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Modified adenoviruses
    Patent number: 12098383
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: September 24, 2024
    Assignee: Gritstone bio, Inc.
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • MULTIEPITOPE VACCINE CASSETTES
    Publication number: 20240285739
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: August 29, 2023
    Publication date: August 29, 2024
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • MULTI-SPECIFIC ANTIBODIES AND METHODS OF USE
    Publication number: 20240279343
    Abstract: Provided herein are multispecific antigen binding proteins that selectively bind a particular KKLC-1 (CT-83) shared antigen and CD3, as well as related methods, kits, and compositions. Included herein are multispecific antigen binding proteins with a circularized conformation.
    Type: Application
    Filed: July 12, 2023
    Publication date: August 22, 2024
    Inventors: Isaac J. Rondon, Christine Janson, Manankumar Anilkumar Shah, Karin Jooss
  • KRAS-NEOANTIGEN THERAPIES
    Publication number: 20240238397
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, such as in subjects with cancer that includes (1) a solid tumor expressing the KRAS-associated MHC class I neoepitope, (2) colorectal cancer (CRC), (3) non-small cell lung cancer (NSCLC), and/or (4) pancreatic ductal adenocarcinoma (PDA).
    Type: Application
    Filed: March 15, 2024
    Publication date: July 18, 2024
    Inventors: Raphael Rousseau, Karin Jooss, Christine Denise Palmer, Amy Rachel Rappaport