Patents by Inventor Karin Leontein
Karin Leontein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11850334Abstract: There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.Type: GrantFiled: October 3, 2019Date of Patent: December 26, 2023Assignee: Carmeda ABInventors: Dagmar Pikas, Johan Riesenfeld, Karin Leontein, Eva Koch, Stefan Oscarson
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Patent number: 11529441Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.Type: GrantFiled: January 3, 2020Date of Patent: December 20, 2022Assignee: W. L. Gore & Associates, Inc.Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
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Patent number: 11497838Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: GrantFiled: June 26, 2020Date of Patent: November 15, 2022Assignee: W. L. Gore & Associates, Inc.Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Publication number: 20210379253Abstract: There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.Type: ApplicationFiled: October 3, 2019Publication date: December 9, 2021Inventors: Dagmar Pikas, Johan Riesenfeld, Karin Leontein, Eva Koch, Stefan Oscarson
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Publication number: 20200324027Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: ApplicationFiled: June 26, 2020Publication date: October 15, 2020Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 10736999Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: GrantFiled: August 23, 2017Date of Patent: August 11, 2020Assignee: W.L Gore & Associates, Inc.Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Publication number: 20200139020Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.Type: ApplicationFiled: January 3, 2020Publication date: May 7, 2020Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
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Patent number: 10561766Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.Type: GrantFiled: September 14, 2016Date of Patent: February 18, 2020Assignee: W. L. Gore & Associates, Inc.Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
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Publication number: 20180326118Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicant: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Patent number: 10064978Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: GrantFiled: September 19, 2014Date of Patent: September 4, 2018Assignee: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20170368237Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: ApplicationFiled: August 23, 2017Publication date: December 28, 2017Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 9764068Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: GrantFiled: July 7, 2016Date of Patent: September 19, 2017Assignee: W.L. Gore and Associates Inc.Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Publication number: 20170072116Abstract: According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.Type: ApplicationFiled: September 14, 2016Publication date: March 16, 2017Inventors: Per Antoni, Karin Leontein, Mei Li, Robert L. Cleek, Paul D. Drumheller
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Publication number: 20170014553Abstract: According to the invention there is provided inter alia an implantable medical device with coatings comprising an immobilized heparin moiety and elutable paclitaxel and to methods for making such devices.Type: ApplicationFiled: March 13, 2015Publication date: January 19, 2017Inventors: Per Antoni, Karin LEONTEIN, Lars VINCENT, Robert L. Cleek, Paul D. DRUMHELLER, Theresa A. HOLLAND, Todd J. JOHNSON, Krzysztof R. PIETRZAK, Bruce STEINHAUS
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Publication number: 20160310646Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: ApplicationFiled: July 7, 2016Publication date: October 27, 2016Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 9408950Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: GrantFiled: July 2, 2015Date of Patent: August 9, 2016Assignee: W.L. Gore & Associates, Inc.Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Publication number: 20150367040Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: ApplicationFiled: July 2, 2015Publication date: December 24, 2015Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 9101696Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.Type: GrantFiled: March 9, 2012Date of Patent: August 11, 2015Assignee: W.L. Gore & Associates, Inc.Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
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Patent number: 8992963Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: GrantFiled: September 15, 2009Date of Patent: March 31, 2015Assignee: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20150045508Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: September 19, 2014Publication date: February 12, 2015Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg