Patents by Inventor Karin Maria Balss

Karin Maria Balss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for the non-destructive assessment of the quantitative spatial distribution of components of a medical device
    Patent number: 7478008
    Abstract: A method and system for the non-destructive analysis of medical devices uses a confocal Raman microscope and other non-destructive analytical tools to assess the spatial distribution of components of an object such as the distribution of an active pharmaceutical ingredient (API) within a polymer matrix. In a preferred embodiment, confocal Raman spectroscopy was used to differentiate each component found in the sirolimus-eluting coronary stent. The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents. The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar substrates.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: January 13, 2009
    Assignee: Cordis Corporation
    Inventors: Karin Maria Balss, Gerard Llanos, Cynthia Anne Maryanoff, George Papandreou, Vladimir Veselov
  • SYSTEM AND METHOD FOR THE NON-DESTRUCTIVE ASSESSMENT OF THE QUANTITATIVE SPATIAL DISTRIBUTION OF COMPONENTS OF A MEDICAL DEVICE
    Publication number: 20080228428
    Abstract: A method and system for the non-destructive analysis of medical devices uses a confocal Raman microscope and other non-destructive analytical tools to assess the spatial distribution of components of an object such as the distribution of an active pharmaceutical ingredient (API) within a polymer matrix. In a preferred embodiment, confocal Raman spectroscopy was used to differentiate each component found in the sirolimus-eluting coronary stent. The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents. The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar substrates.
    Type: Application
    Filed: July 19, 2007
    Publication date: September 18, 2008
    Inventors: Karin Maria Balss, Gerard Llanos, Cynthia Maryanoff, George Papandreou, Vladimir Veselov