Abstract: Compositions and methods are provided for preparing nanosized biologically active agents, including agents formulated for target specific drug delivery. The nanosized agents are prepared with supercritical carbon dioxide as an antisolvent, providing nanoparticles whose size, shape, and surroundings are well-controlled. The nanoparticles are made of small molecules, e.g. drugs, anti-oxidants, luciferin, polypeptides, e.g. oligopeptides; polynucleotides, e.g. siRNA, antisense oligonucleotides, etc. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc.

Abstract: Chiral arylcarboxamide-containing alkenes and alkoxysilanes and polysiloxane polymers containing chiral arylcarboxamide-substituted side chains and methods for their preparation are disclosed. The chiral arylcarboxamide-containing alkenes are used to prepare the chiral arylcarboxamide-containing polysiloxane polymers which are useful as stationary phase coatings in gas-liquid and supercritical fluid chromatography in the separation and analysis of enantiomeric and other stereoisomeric mixtures of various substances. The chiral arylcarboxamide containing alkoxysilanes are reactive towards silica particles for use as packing in liquid chromatography columns.