Patents by Inventor Karin R. Tietje

Karin R. Tietje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAZABICYCLIC CENTRAL NERVOUS SYSTEM ACTIVE AGENTS
    Publication number: 20120208820
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Application
    Filed: January 31, 2012
    Publication date: August 16, 2012
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • Diazabicyclic central nervous system active agents
    Patent number: 8119635
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: February 21, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors
    Patent number: 7872010
    Abstract: Provided herein are compositions of a class of substituted diazabicycloalkane derivative compounds, which are useful as modulators of nicotinic acetylcholine receptors. The compounds are useful in treating conditions and disorders prevented by, or ameliorated by, nicotinic acetylcholine receptors.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: January 18, 2011
    Assignee: Abbott Laboratories
    Inventors: Jennifer M. Frost, Jianguo Ji, Tao Li, Diana L. Nersesian, Karin R. Tietje
  • DIAZABICYCLIC CENTRAL NERVOUS SYSTEM ACTIVE AGENTS
    Publication number: 20100016277
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Application
    Filed: August 19, 2009
    Publication date: January 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • Diazabicyclic central nervous system active agents
    Patent number: 7598236
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: December 15, 2007
    Date of Patent: October 6, 2009
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • Indoles are cannabinoid receptor ligands
    Patent number: 7560481
    Abstract: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: July 14, 2009
    Assignee: Abbott Laboratories
    Inventors: Jennifer M. Frost, Karin R. Tietje, Michael J. Dart, Michael D. Meyer
  • NOVEL INDOLES ARE CANNABINOID RECEPTOR LIGANDS
    Publication number: 20090149501
    Abstract: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 11, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Jennifer M. Frost, Karin R. Tietje, Michael J. Dart, Michael D. Meyer
  • Substituted Diazabicycloalkane Derivates
    Publication number: 20080275048
    Abstract: Compounds of formula (I) Z-Ar1—Ar2 ??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
    Type: Application
    Filed: June 3, 2008
    Publication date: November 6, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Jennifer M. Frost, Jianguo Ji, Tao Li, Diana L. Nersesian, Karin R. Tietje
  • Substituted diazabicycloalkane derivatives
    Patent number: 7399765
    Abstract: Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: July 15, 2008
    Assignee: Abbott Laboratories
    Inventors: William H. Bunnelle, Jianguo Ji, Tao Li, Jennifer M. Pace, Karin R. Tietje, Kathleen H. Mortell, Diana L. Nersesian, Michael R. Schrimpf
  • Diazabicyclic central nervous system active agents
    Patent number: 7319106
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: January 15, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Azabicyclic compounds are central nervous system active agents
    Patent number: 7135484
    Abstract: Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: November 14, 2006
    Assignee: Abbott Laboratories
    Inventors: Michael J. Dart, Xenia B. Searle, Karin R. Tietje, Richard B. Toupence
  • Diazabicyclic central nervous system active agents
    Patent number: 6809105
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: October 26, 2004
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Diazabicyclic central nervous system active agents
    Publication number: 20040186107
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: March 26, 2004
    Publication date: September 23, 2004
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Azabicyclic compounds are central nervous system active agents
    Publication number: 20040152724
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: August 12, 2003
    Publication date: August 5, 2004
    Inventors: Michael J. Dart, Xenia B. Searle, Karin R. Tietje, Richard B. Toupence
  • Diazabicyclic central nervous system active agents
    Publication number: 20020019388
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: April 12, 2001
    Publication date: February 14, 2002
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Pace, Kevin B. Sippy
  • Bicyclic substituted hexahydrobenz ?e! isoindole alpha-1 adrenergic antagonists
    Patent number: 5792767
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 11, 1998
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, James F. Kerwin, Jr., Suzanne A. Lebold, Edmund L. Lee, John K. Pratt, Kevin B. Sippy, Karin R. Tietje, Diane M. Yamamoto
  • Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
    Patent number: 5597823
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 28, 1997
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, Steven W. Elmore, James F. Kerwin, Jr., Suzanne A. Lebold, Edmund L. Lee, Kevin B. Sippy, Karin R. Tietje, Michael D. Wendt
  • Bicyclic substituted hexahydrobenz[e]isoindole .alpha.-1 adrenergic antagonists
    Patent number: 5521181
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: May 28, 1996
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, William A. Carroll, Irene Drizin, Suzanne A. Lebold, Edmund L. Lee, Kevin B. Sippy, Karin R. Tietje, Diane M. Yamamoto, James F. Kerwin, Jr.
  • Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors
    Patent number: 5288749
    Abstract: The present invention provides tertiary and secondary amine compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and which inhibit serotonin (5-hydroxytryptamine, 5-HT) uptake.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: February 22, 1994
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, John F. DeBernardis, Rajnandan Prasad, Kevin B. Sippy, Karin R. Tietje
  • Adenosine-5'-carboxamides and method of use
    Patent number: 4167565
    Abstract: A method of controlling undesired animals including rodents, coyotes and birds which comprises making available to said animals an edible composition containing, as the active ingredient, a lethal dose of a compound represented by formula ##STR1## wherein R is H, loweralkyl or acetyl; R.sub.1 is H or acetyl; R.sub.2 is H, Cl or NH.sub.2 ; R.sub.3 is H, loweralkyl, alkoxy, cycloalkyl or hydroxyalkyl; R.sub.4 and R.sub.5 are each H, acetyl or propionyl, or when taken together form a p-chlorobenzylidene, a carbonate or an ethoxymethylene moiety; in a suitable carrier.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: September 11, 1979
    Assignee: Abbott Laboratories
    Inventors: Herman H. Stein, Raj N. Prasad, Karin R. Tietje, Anthony K. L. Fung