Patents by Inventor Karin Sandager Nielsen

Karin Sandager Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GABAA receptor ligand
    Patent number: 11396510
    Abstract: The present invention relates to 2-(3-(3-(2,4-dimethoxypyrimidin-5-yl)phenyl)-3H-imidazo[4,5-b]pyridin-6-yl)propan-2-ol, which is useful as a GABA receptor modulator. In one embodiment, said compound is useful in the treatment of pain, neuropathic pain and/or itch.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: July 26, 2022
    Assignee: Saniona A/S
    Inventors: Janus S. Larsen, Dipak Amrutkar, Thomas Amos Jacobsen, Tino Dyhring, Karin Sandager Nielsen
  • Selective Agonist Of Alpha6 Containing nAChRs
    Publication number: 20220143014
    Abstract: The present invention relates to a subtype selective partial agonist of ?6 containing nicotinic acetylcholine receptors. Due to its uniquely selective and functional profile, 9-methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane may be useful in the treatment, prevention and/or alleviation of a disease, disorder and/or condition which is responsive to activation of a nicotinic acetylcholine receptor (nAChR) in a subject, wherein the nAChR comprises at least one cholinergic receptor nicotinic alpha 6 subunit (nAChR?6). Preferably, said disease, disorder and/or condition is a Parkinsonian disorder or pain.
    Type: Application
    Filed: December 1, 2020
    Publication date: May 12, 2022
    Inventors: Tino Dyhring, Dan Peters, Palle Christophersen, Karin Sandager Nielsen, Lars Ulrik Wahlberg, Dipak Amrutkar
  • POTASSIUM CHANNEL MODULATORS
    Publication number: 20210380571
    Abstract: Provided are compounds and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.
    Type: Application
    Filed: January 15, 2021
    Publication date: December 9, 2021
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • A GABAA Receptor Ligand
    Publication number: 20210332042
    Abstract: The present invention relates to 2-(3-(3-(2,4-dimethoxypyrimidin-5-yl)phenyl)-3H- imidazo[4,5-b]pyridin-6-yl)propan-2-ol, which is useful as a GABA receptor modulator. In one embodiment, said compound is useful in the treatment of pain, neuropathic pain and/or itch.
    Type: Application
    Filed: September 13, 2019
    Publication date: October 28, 2021
    Inventors: Janus S. LARSEN, Dipak AMRUTKAR, Thomas Amos JACOBSEN, Tino DYHRING, Karin Sandager NIELSEN
  • Potassium channel modulators
    Patent number: 10717728
    Abstract: Provided are compounds of the formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: July 21, 2020
    Assignee: Cadent Therapeutics, Inc.
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • POTASSIUM CHANNEL MODULATORS
    Publication number: 20190352293
    Abstract: Provided are compounds and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.
    Type: Application
    Filed: June 4, 2019
    Publication date: November 21, 2019
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • Potassium channel modulators
    Patent number: 10351553
    Abstract: Provided herein are compounds of the formula: or pharmaceutically acceptable salts thereof, and compositions comprising such compounds for use in the treatment of diseases or conditions responsive to modulation of the small conductance calcium-activated potassium channel (SK channel).
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: July 16, 2019
    Assignee: Cadent Therapeutics, Inc.
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • Selective Agonist Of a6 Containing nAChRs
    Publication number: 20180311238
    Abstract: The present invention relates to a subtype selective partial agonist of ?6 containing nicotinic acetylcholine receptors. Due to its uniquely selective and functional profile, 9-methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane may be useful in the treatment, prevention and/or alleviation of a disease, disorder and/or condition which is responsive to activation of a nicotinic acetylcholine receptor (nAChR) in a subject, wherein the nAChR comprises at least one cholinergic receptor nicotinic alpha 6 subunit (nAChRa6). Preferably, said disease, disorder and/or condition is a Parkinsonian disorder or pain.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 1, 2018
    Inventors: Tino Dyhring, Dan Peters, Palle Christophersen, Karin Sandager Nielsen, Lars Ulrik Wahlberg, Dipak Amrutkar
  • POTASSIUM CHANNEL MODULATORS
    Publication number: 20180215746
    Abstract: Provided are compounds and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • METHODS FOR THE TREATMENT OF TREMORS BY POSITIVE MODULATION OF SK CHANNELS
    Publication number: 20180207138
    Abstract: Provided herein is the use of one or more small-conductance calcium-activated potassium channel positive modulators (SK positive modulators) for the treatment of tremors.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Martin R. Jefson, Gregg F. Keaney, Karin Sandager Nielsen
  • Potassium channel modulators
    Patent number: 9975886
    Abstract: Provided are compounds of the formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: May 22, 2018
    Assignee: Cadent Therapeutics, Inc.
    Inventors: Dipak Vasantrao Amrutkar, Kelly Foster, Thomas Amos Jacobsen, Martin R. Jefson, Gregg F. Keaney, Janus Schreiber Larsen, Karin Sandager Nielsen
  • Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    Patent number: 9133184
    Abstract: The present application discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the application discloses the use of these compounds, a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: September 15, 2015
    Assignee: ANIONA APS
    Inventors: Dan Peters, Gordon Munro, Elsebet Ostergaard Nielsen, Karin Sandager Nielsen
  • CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
    Publication number: 20140235669
    Abstract: The present application discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the application discloses the use of these compounds, a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: April 28, 2014
    Publication date: August 21, 2014
    Applicant: ANIONA APS
    Inventors: Dan PETERS, Gordon MUNRO, Elsebet Ostergaard NIELSEN, Karin Sandager NIELSEN
  • Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    Patent number: 8697721
    Abstract: The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: April 15, 2014
    Assignee: Aniona APS
    Inventors: Dan Peters, Elsebet Østergaard Nielsen, Karin Sandager Nielsen, Gordon Munro
  • CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
    Publication number: 20130040985
    Abstract: The present application discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the application discloses the use of these compounds, a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: January 14, 2011
    Publication date: February 14, 2013
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Gordon Munro, Elsebet Østergaard Nielsen, Karin Sandager Nielsen
  • CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
    Publication number: 20120088789
    Abstract: The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: May 6, 2010
    Publication date: April 12, 2012
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Elsebet Østergaard Nielsen, Karin Sandager Nielsen, Gordon Munro
  • 2-(phenylamino) benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
    Patent number: 7960561
    Abstract: This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: June 14, 2011
    Assignee: Neurosearch A/S
    Inventors: Ulrik Svane Sørensen, Lene Teuber, Dan Peters, Dorte Strøbæk, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen
  • NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS
    Publication number: 20110085978
    Abstract: This invention provides novel quinolinylamide derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
    Type: Application
    Filed: March 13, 2009
    Publication date: April 14, 2011
    Applicant: NeuroSearch A/S
    Inventors: Dan Peters, Lars Christian Rønn, Karin Sandager Nielsen, Jørgen Scheel-Krüger
  • NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS
    Publication number: 20110059019
    Abstract: This invention provides novel aryl piperazine derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, 5HT1A and 5-HT2A receptor subtypes, and in particular useful for the treatment of neuropsychiatric disorders, incl. schizophrenia.
    Type: Application
    Filed: January 29, 2009
    Publication date: March 10, 2011
    Applicant: NeuroSearch A/S
    Inventors: Dan Peters, Lars Christian Rønn, Karin Sandager Nielsen, Jørgen Scheel-Krüger
  • NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS
    Publication number: 20110034527
    Abstract: This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: October 21, 2010
    Publication date: February 10, 2011
    Inventors: Ulrik Svane SØRENSEN, Lene Teuber, Dan Peters, Dorte Strøbæk, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen