Abstract: The invention relates to novel compositions comprising magnolol and honokiol wherein the mol ratio of magnolol to honokiol is less than 0.6 as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Abstract: The present invention relates to novel compositions comprising magnolol and/or honokiol and chondroitin as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Abstract: The present invention is directed to the use of a compound selected from the group consisting of ?-carotene, lutein, lycopene and ?-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 for maintaining the energy metabolism, the energy flow and/or the energy production in skin or of skin of animals including humans, for maintaining the respiratory function of the skin of animals including humans, for energizing the skin, maintaining and supporting the radiance and natural glow of the skin of animals including humans and for promoting a healthy appearance of the skin of animals including humans for preventing UV-A radiation-induced mtDNA mutagenesis in skin of animals including humans, as well as for the manufacture of a composition, preferably an orally applicable composition, for these uses and the corresponding methods.

Abstract: ?-Cryptoxanthin and esters thereof may find use for promoting an increased protein formation and/or prevention of loss of proteins in humans and animals.

Abstract: Methods to treat, prevent, and modulate aging of the skin are provided. More particularly, methods are provided for treating or preventing non-light induced skin aging in an organism and for reducing the basal MMP-10 expression in unirradiated cells of an organism and/or reducing the basal MMP-1 RNA transcription and protein translation in unirradiated cells of an organism, which include administering an effective amount of ?-carotene, a precursor of ?-carotene, a derivative of ?-carotene, a salt of ?-carotene, or a combination thereof to an organism in need thereof. Also provided are compositions for treating and preventing non-light induced aging of the skin.

Abstract: Methods and compositions—particularly compositions containing ?-carotene—for modulating the expression of genes that effect or influence cellular health or protect against cellular damage, e.g., skin aging, are provided. More particularly, a method is provided for screening for a compound that modulates an effect of UV irradiation on eukaryotic cells. Methods and compositions for ameliorating the effects of non-UV radiation induced skin aging and for modulating UVA-induced gene expression on skin aging are also provided. Further provided are methods and compositions for enhancing UVA-induced tanning of the skin, for promoting cell differentiation in UVA-irradiated cells of an organism, and for modulating stress-induced induction of a gene in an organism.

Abstract: Lycopene can be used in the primary prevention and incidence risk reduction of non-cancerous symptoms and/or pathologies (i.e., the prophylactic supplementation of the healthy subjects), in the treatment or the coadjuvant treatment of non-can-cerous symptoms and/or pathologies (i.e. the supplementation as therapy or accompanying a running therapy) and in the secondary prevention of non-cancerous symptoms and/or pahtologies (i.e., the supplementation after a successful therapy for the prevention of the relapse), which are associated with, favored by or caused by androgen signalling or which are sensitive to a reduction of androgen signalling.

Abstract: The invention is concerned with the use of lycopene, optionally in combination with vitamin E and/or C or other biologically active ingredients as disclosed in the specification, in the manufacture of a composition for the primary and secondary prevention of angiogenesis-associated pathologies and coadjuvant treatment thereof; as well as with particular novel formulations comprising lycopene.