Abstract: The present invention provides compositions and methods for the treatment of neoplasms, in particular, by targeting of quiescent and proliferating cancers cells with DYRK1 inhibitor in combination with other treatments effective against certain neoplastic conditions, in particular, anti-cancer treatment with a MEK inhibitor or a b-RAF inhibitor, or a KRAS inhibitor.

Abstract: A clad mode stripper is provided on a passive double-clad fiber guiding amplified light signal downstream from a gain block. The fiber is configured with an upstream end stripped from a protective coating. A light absorbing mixture is applied to the exposed cladding of the fiber receiving unwanted pump light. The mixture includes a host material and a plurality of diffusers which are operative to scatter cladding light incident thereon and embedded in the host material so as to define upstream and downstream decoupling zones. The diffusers are selected from either silicone polymers with a refractive index lower than that of the host material or from metal particles and lower the effective refractive index of the mixture so that it at most equal to that of the cladding. The mixture is operative to gradually remove substantially entire unwanted light guided by the cladding so that the downstream decoupling zone is heated at a temperature lower than that of the upstream zone.

Abstract: A clad mode stripper is provided on a passive double-clad fiber guiding amplified light signal downstream from a gain block. The fiber is configured with an upstream end stripped from a protective coating. A light absorbing mixture is applied to the exposed cladding of the fiber receiving unwanted pump light. The mixture includes a host material and a plurality of diffusers which are operative to scatter cladding light incident thereon and embedded in the host material so as to define upstream and downstream decoupling zones. The diffusers are selected from either silicone polymers with a refractive index lower than that of the host material or from metal particles and lower the effective refractive index of the mixture so that it at most equal to that of the cladding. The mixture is operative to gradually remove substantially entire unwanted light guided by the cladding so that the downstream decoupling zone is heated at a temperature lower than that of the upstream zone.