Abstract: A pharmaceutical packaging system includes a substrate having a first surface, a first hollow cavity accessible through a first opening in the first surface, and a second hollow cavity accessible through a second opening in the first surface. The first and second hollow cavities are spaced apart and isolated from one another on the substrate. A cover is attached to at least a first portion of the first surface of the substrate surrounding the first opening and a second portion of the first surface of the substrate surrounding the second opening so as to provide a first seal for the first hollow cavity and a second seal for the second hollow cavity. At least one orally-administered medicament is contained within one of the first and second hollow cavities, and a first topically-applied medicament is contained within the other of the first and second hollow cavities.