Abstract: A patient temperature control system is disclosed that includes a heat exchange system configured to heat or cool a fluid, a circulating pump configured to circulate the fluid through the heat exchanger and at least one interconnectable pad and a control one or more processors and a non-transitory computer-readable medium having stored thereon logic. The logic, when executed by the one or more processors, causes operations including initiation of a targeted temperature management therapy, obtaining of measurements from fluid temperature sensors, a volumetric flow rate sensor and a patient temperature sensor, determining a level of patient heat generation based on one or more of the obtained measurements, and transmitting, via one or more wireless signals, data indicating the level of patient heat generation to a network device.