Patents by Inventor Karinel Nieves Merced

Karinel Nieves Merced has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes
    Patent number: 10173974
    Abstract: The marine natural product (?)-8,15-diisocyano-11(20)-amphilectene, isolated from the Caribbean sponge Svenzea flava, was used as scaffold to synthesize five new products, all of which were tested against laboratory strains of Plasmodium falciparum and Mycobacterium tuberculosis H37Rv. The scaffold contains two isocyanide units that are amenable to chemical manipulation, enabling them to be elaborated into a small library of sulfur and selenium compounds. The scaffold along with its isothio- and isoselenocyanate analogs has low to sub-micro molar antiplasmodial activity.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 8, 2019
    Assignee: University of Puerto Rico
    Inventors: Abimael D. Rodríguez Pierluissi, Karinel Nieves Merced